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MINI REVIEW article

Front. Cell Dev. Biol.

Sec. Cell Growth and Division

This article is part of the Research TopicThe Role of Platelet Derivatives in Regenerative MedicineView all 7 articles

Platelet Derivatives in Oral and Maxillofacial Surgery: Classification, and Clinical Applications

Provisionally accepted
Antonio ScaranoAntonio Scarano1*Sergio Alexandre GehrkeSergio Alexandre Gehrke2Ermal PashajErmal Pashaj3Nicolai GianlucaNicolai Gianluca4Luan MavriqiLuan Mavriqi5Edit XhajankaEdit Xhajanka3sergio Rexhep Tarisergio Rexhep Tari6
  • 1University of Studies G. d'Annunzio Chieti and Pescara, Chieti, Italy
  • 2Universidad Catolica San Antonio de Murcia, Murcia, Spain
  • 3Catholic University Our Lady of Good Council, Tiran, Albania, Tirana, Albania
  • 4Universita degli Studi di Roma Tor Vergata, Rome, Italy
  • 5Universiteti i Tiranes, Tirana, Albania
  • 6Universita degli Studi Gabriele d'Annunzio Chieti Pescara, Chieti, Italy

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Several studies on the use of platelet concentrates show different results. For example, while many studies demonstrate significant benefits of using PCs in tissue regeneration, others report modest or no results, creating uncertainty about the actual clinical usefulness of these PCs. This confusion also arises from the different protocols used to prepare platelet concentrates, which became clearer after the classification of PCs based on the presence of leukocytes and the organization of fibrin. Currently, we have numerous devices available to obtain PCs with specific characteristics typical of each method, such as APG, PRF, PRGF, CGF, etc. On one hand, this wide range of options offered by companies creates confusion; on the other hand, it allows us to have systems that provide a uniform product for all operators by standardizing centrifugal force, the type of vial used, its inclination, and rotation time. The aim of this mini review is to provide an overview of the applications of Autologous Platelet Concentrates (APCs) and their clinical application. mechanisms of action.

Keywords: growth factors, Oral maxillofacial surgery, Platelet concentrates, Platelet-Rich Plasma, Tissue Regeneration

Received: 27 Dec 2025; Accepted: 10 Feb 2026.

Copyright: © 2026 Scarano, Gehrke, Pashaj, Gianluca, Mavriqi, Xhajanka and Tari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Antonio Scarano

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material