Microplastic Exposure and Human Health Risks Across the Life Cycle: A Focus on Reproduction, Development, and Aging

Guosheng Liu^1,2Tian Shi^1,2*Shengyao Tang^1,2*Xia Huang¹Xiao Liu^1,2

• ¹Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Enshi, China
• ²Minda Hospital of Hubei Minzu University, Enshi, China

Microplastic pollution has emerged as a critical global environmental and public health challenge. These small plastic particles of diverse origins are ubiquitously distributed in aquatic, atmospheric, terrestrial, and food systems, entering the human body through ingestion, inhalation, and dermal contact, thereby creating complex lifelong exposure scenarios. Accumulating evidence indicates that microplastics (MPs) not only pose threats to key early-life stages—including reproductive health, pregnancy maintenance, fetal development, and child growth—but may also systematically accelerate the aging process and increase the risk of age-related diseases. This review provides a comprehensive synthesis of the physicochemical properties, environmental distribution, human exposure pathways, and life-cycle health impacts of MPs. It elaborates on their specific adverse effects on the reproductive system and their interference with fetal and child development. Furthermore, it delves into the core molecular mechanisms by which MPs drive cellular and tissue aging, primarily through the induction of mitochondrial dysfunction, oxidative stress, and chronic inflammation. The review also summarizes current research limitations concerning methodological standardization and epidemiological evidence, while outlining priority areas for future investigation. By integrating evidence across the life course, this review aims to establish a solid theoretical foundation for understanding the composite health risks of MPs, identifying vulnerable life stages, and informing the development of scientific prevention and intervention strategies.