MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Lamins' role in osteosarcoma
1. DAHFMO – Unit of Histology and Medical Embryology, Universita degli Studi di Roma La Sapienza, Rome, Italy
2. Dept. of Life Science and Public Health, Section of Histology and Embryology, Università Cattolica del Sacro Cuore, Rome, Italy
3. Oncology and Experimental Neuroscience Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
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Abstract
Osteosarcoma (OS) is a rare and highly aggressive bone tumor that can develop in several skeletal segments, although it predominantly affects the long bones. This cancer mostly occurs in adolescents, young adults and people older than 60. There are many questions still open regarding osteosarcoma biology and the efficacy of current treatments. Recent research has increasingly emphasized the critical role of mechanotransduction as a key regulator of critical cellular functions. Notably, emerging evidence highlights the nucleus as an active player in mechanosensing and mechanotransduction processes within the bone tissue. The nuclear envelope is composed of several proteins, among which lamins. These proteins are essential components of the inner nuclear membrane (INM) exerting many different functions, also known for having a pivotal role in mechanotransduction and bone cell differentiation. In this review, we analyze the state of the art regarding the lamins role in bone cancer biology.
Summary
Keywords
Bone tissue, Lamins, Mechanotransduction, Nuclear Envelope, Osteosarcoma
Received
08 January 2026
Accepted
20 February 2026
Copyright
© 2026 Bagnato and Peruzzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Barbara Peruzzi
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