ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Implantation of Autogenic and Decellularized Xenogenic Grafts for Tissue Repair in Experiment
Provisionally accepted
Alexander V. Pechersky1*
Viktor I. Pechersky2Ilya A. Barsuk2Vladimir N. Vilyaninov2Viktor N. Alexandrov2
Vladimir Semiglazov3- 1Medical Center “Professor”, St. Petersburg, Russia
- 2Voenno-medicinskaa akademia imeni S M Kirova Ministerstva oborony Rossijskoj Federacii, Saint Petersburg, Russia
- 3FBGU Nacional'nyj medicinskij issledovatel'skij centr onkologii imeni N N Petrova Ministerstva zdravoohranenia Rossijskoj Federacii, Saint Petersburg, Russia
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Introduction: With extensive tissue damage, the body is unable to restore their integrity on its own. Implantation of autogenic and decellularized xenogenic grafts opens up new possibilities for regeneration of damaged corresponding tissues. Methods: The pilot experimental study was conducted on a model of healing of grade III B skin burn wounds in Wistar rats. After removal of the necrotized tissues, autogenous and decellularized xenogenic grafts were implanted into the blood-supplying tissues of the burn wounds. Results: The pilot experimental study showed that implantation of autogenic and decellularized xenogenic grafts in the experimental zone led to the formation of multiple regeneration sites, almost ten times higher than the marginal epithelialization of the control zone. The proportion of epithelialization of the experimental zone initiated by the installed grafts was more than 90%, and the proportion of marginal epithelialization of the control zone was less than 10%. The completion of epithelialization of skin burn wounds with a predominance of epithelialization of the experimental zone led to the healing of burn wounds. The tightening of the wound edges by scar tissue was minimal. Conclusion: Implantation of autogenic or decellularized xenogenic grafts can potentially be used to repair any tissues after their damage or disease. The results obtained are preliminary, requiring verification on a wider sample of experimental animals. The use of this methodology to repair tissues with a more complex structure than the skin, for increase the functioning of the parenchyma of various organs requires further study.
Keywords: autogenic and decellularized xenogenic grafts, Innate and Acquired Immunity, Pluripotent Stem Cells, Regeneration, Tissue damage, Tissue-specific antigens
Received: 14 Jan 2026; Accepted: 16 Feb 2026.
Copyright: © 2026 Pechersky, Pechersky, Barsuk, Vilyaninov, Alexandrov and Semiglazov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Alexander V. Pechersky
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