ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Extra-intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1577947
This article is part of the Research TopicCommunity Series in the Immunological Role of the Maternal Microbiome in Pregnancy: Volume IIView all 4 articles
The effects of cervical cerclage on vaginal microbiota and its metabolites in pregnant women
Provisionally accepted
- Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Fujian, China
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Cervical cerclage is widely used to reduce the risk of preterm birth in pregnant women. The effect of cervical cerclage on the vaginal microbiota and its metabolites are not fully clear. The purpose of this study was to explore the influence of cervical cerclage on the vaginal microbiota and its metabolites. Our results exhibited that the clinical characteristics (WBC, neutrophil, lymphocyte, monocytes, platelet, NLR, PLR, SII, SIRI, and C-reactive protein) and α-diversity (Observed, Shannon, Chao1, and Simpson indexes) of vaginal microbiota weren't altered in pregnancy after the cervical cerclage. 16S rRNA gene sequencing found the relative abundance of Muribaculaceae and Blautia were significantly increased in the pos-cerclage group compared with the pre-cerclage group, but the relative abundance of Sneathia was significantly reduced. In addition, the volcano plot revealed that a total of 19 metabolites [including Alpha-hydroxyalprazolam, LPE (18:1(9Z)/0:0), PS(16:0/15:0), N-Acetylhistamine, carnitine, pseudouridine, allopregnanolone, et al.] were significantly changed in pregnancy after the cervical cerclage. Pathway analysis based on the KEGG database exhibited that the changes of vaginal microbiota and its metabolites major involved in the purine metabolism and amino acid metabolism. The alteration in vaginal microbiota and its metabolites induced by cervical cerclage is associated with the therapeutic efficacy of cervical cerclage. Further studies are needed to explore how vaginal microbiota effects the outcomes of pregnancy.
Keywords: Cervical cerclage, Pregnant Women, Clinical Characteristics, vaginal microbiota, vaginal metabolites
Received: 18 Feb 2025; Accepted: 16 May 2025.
Copyright: © 2025 Zhang, Wang, Zhang, Xu, Zheng, Lv and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mian Pan, Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Fujian, China
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