REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1594834
This article is part of the Research TopicGut Microbiota and Age-Related Disorders: From Mechanisms to TherapiesView all 6 articles
The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms
Provisionally accepted
- 1College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China
- 2The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, Jilin, China
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Ischemic stroke (IS) is a severe central nervous system disorder characterized by high incidence, disability, mortality, and recurrence rates, along with numerous complications. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway between the brain and the gut, which can influence the onset and progression of IS through neural, immunoregulatory, and gut metabolite pathways. Recent preclinical and clinical evidence supports the use of fecal microbiota transplantation (FMT), probiotics and prebiotics, dietary interventions, and antibiotics as strategies to suppress neuroinflammation in IS, protect the blood-brain barrier, modulate immune responses, and improve stroke outcomes. In this review, we summarize the manifestations of innate inflammation and adaptive immunity following the onset of IS, highlight the interactions between the MGBA and post-stroke neuroinflammation, and discuss current therapeutic measures, thus providing insights for the development of novel treatment strategies in the future.
Keywords: Dysbiosis1, gut microbiota2, ischemic stroke3, microbiota-gut-brain-axis4, neuroinflammation5
Received: 17 Mar 2025; Accepted: 03 Jun 2025.
Copyright: © 2025 Xie, Yan, Yang, Sun and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weimin Zhang, The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, Jilin, China
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