Frontiers in Chemical Biology

Volume 4 - 2025

Original Research

Published on 14 May 2025

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

Cécile Exertier
Lorenzo Antonelli
Vittorio Brufani
Gianni Colotti
Andrea Ilari
Annarita Fiorillo

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1605579

1,784 views

Original Research

Published on 12 May 2025

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

Marika Attili
Sonia Valentini
Maria Pesavento
Marco Ballarotto
Viviana Scognamiglio
Alfredo Pontecorvi
Antonio Macchiarulo
Fulvio Saccoccia
Fabiola Moretti

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1576640

2,635 views

Original Research

Published on 23 Apr 2025

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

Carla Luciana Padilla Franzotti
Nicolas Palopoli
Juliana Palma
Gustavo Pierdominici-Sottile

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1538350

1,279 views

Editorial

Published on 03 Apr 2025

Editorial: New developments in bioinorganic and bioorganic chemistry

Isabel Correia
Sylvia M. Draper

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1586841

1,430 views

Mini Review

Published on 28 Feb 2025

Multifaceted roles of STING in tumors: from molecular mechanisms to therapeutic strategies

Aashiq Hussain
Linchun Wen
Rui Wang

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1549003

1,492 views

Review

Published on 25 Feb 2025

Biology and pharmacological inhibition of homeodomain-interacting protein kinases

Adam Štefek
Kamil Paruch

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1441138

1,909 views

Editorial

Published on 14 Feb 2025

Editorial: Bioluminescence and fluorescence molecular imaging in chemical biology

Sung Bae Kim
Giuseppe Sancataldo

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1568300

1,015 views

Editorial

Published on 07 Feb 2025

Editorial: Structure-function relationship of enzymes through a chemical lens

Justin M. Miller
Adam Offenbacher

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1565931

1,414 views

Original Research

Published on 03 Feb 2025

Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions

Aviva Levina
Debbie C. Crans
Peter A. Lay

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1547323

1,461 views

Volume 3 - 2024

Methods

Published on 21 Jan 2025

Evaluation of the microenvironment formed by interferon-β

Mai Yamagishi
Yutaka Hori
Nobutake Suzuki
Yu Peng
Yoshie Harada
Takashi Funatsu
Osamu Ohara
Yoshitaka Shirasaki

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425571

1,590 views

Original Research

Published on 06 Jan 2025

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Claudia Testi
Roberta Piacentini
Alessandro Perrone
Chiara Bartoli
Daniele Leso
Domitilla Pavia
Elisa Pistolesi
Flavio Scipione
Irene Cotronea
Marco Adinolfi Falcone

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1517163

2,099 views

Review

Published on 20 Dec 2024

Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway

Andrew T. Stoltzfus
Sarah L. J. Michel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1503390

1,777 views
1 citation

Original Research

Published on 11 Oct 2024

Molecular interactions at the interface: polyoxometalates of the Anderson-Evans type and lipid membranes

Alina A. Pashkovskaya
Nadiia I. Gumerova
Annette Rompel
Elena E. Pohl

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1454558

2,372 views

Original Research

Published on 10 Sep 2024

Acylfulvenes covalently interact with thioredoxin as an additional cancer target

Laura Slappendel
Xiaodan Liu
Michael R. Macarthur
Charles M. Sharpless
Shana J. Sturla

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1462351

1,351 views

Original Research

Published on 06 Sep 2024

Exploring polyoxometalate speciation: the interplay of concentration, ionic strength, and buffer composition

Maja Ždrnja
Nadiia I. Gumerova
Annette Rompel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1444359

2,698 views
1 citation

Review

Published on 19 Aug 2024

Bioluminescence from the bright and dark sides

Sung-Bae Kim
Tadaomi Furuta

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1459397

5,297 views
4 citations