ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1403722
This article is part of the Research TopicEndocrine Complications of COVID-19: Short and LongView all 12 articles
Effect of COVID-19 inactivated vaccine on anti-Müllerian hormone in Chinese women: a retrospective cohort study
Provisionally accepted
Bao Ming-jie1,2
Leizhen Xia2
Yan Ling3
Quan Wen3Xin Shen3
Ting Wang1,2Si Qian1,2Liqun Wang1,2
Changhua Wang2Shiwei Peng3Yongping Zhang3Shaoping Zhong3Hongying Xu2*
Yuan Zhu1,3*- 1Nanchang University, Nanchang, Jiangxi Province, China
- 2Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi Province, China
- 3Jiangxi Provincial People's Hospital, Nanchang, Jiangxi Province, China
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This study aimed to assess the impact of inactivated COVID-19 vaccine on Anti-Müllerian hormone (AMH) levels in Chinese women. A retrospective analysis was conducted on women aged 18-45 who had undergone two AMH tests between March 2020 and September 2021. Participants were grouped based on vaccine doses, time intervals, and manufacturers. The difference in AMH and the percentage changes in AMH were measured. The results revealed no significant differences in AMH levels between the vaccinated groups (two- and three-dose) and the control group, both in raw and adjusted analyses. In addition, subgroup analysis showed no statistical difference in the total and percentage of AMH changes in different time-interval and manufacturer groups. In conclusion, the number of doses, time interval, and manufacturer of the inactivated COVID-19 vaccine did not affect AMH levels in Chinese women.
Keywords: COVID-19 vaccine1, COVID-19 inactivated vaccine2, anti-müllerian hormone3, ovarian reserve4, Reproductive health5
Received: 19 Mar 2024; Accepted: 01 May 2025.
Copyright: © 2025 Ming-jie, Xia, Ling, Wen, Shen, Wang, Qian, Wang, Wang, Peng, Zhang, Zhong, Xu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongying Xu, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi Province, China
Yuan Zhu, Jiangxi Provincial People's Hospital, Nanchang, 330006, Jiangxi Province, China
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