ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1422881
This article is part of the Research TopicEndocrine Aspects of Gynaecological Cancers, volume IIView all 7 articles
Synergistic Impact of Dysglycemia and HPV on Cervical Cancer Risk: A Potential Mediating Role of Ki-67
Provisionally accepted
- Fujian Medical University, Fuzhou, China
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Background: Cervical cancer, linked to HPV and dysglycemia, lacks clarity on their combined impact. This study explores Ki-67's role in mediating HPV and dysglycemia effects on cervical cancer risk.: This study enrolled patients with abnormal cervical cancer screening results, undergoing colposcopy and conization at Fujian Maternity and Child Health Hospital's Cervical Disease Center from June 2018 to June 2023. Statistical analyses compared baseline characteristics across cervical lesion categories. Multinomial logistic regression examined HPV and dysglycemia associations with LSIL (low-grade squamous intraepithelial lesions), HSIL(high-grade squamous intraepithelial lesions), and cervical cancer, highlighting interaction and mediation analyses involving Ki-67.
Keywords: ：Dysglycemia, HPV, Ki-67, cervical cancer, Interaction OR00: OR(HPV: negative, Hyperglycemia: negative), OR01: OR(HPV: Positive, Hyperglycemia: negative), OR10: OR(HPV: negative, Hyperglycemia: positive), OR11: OR(HPV: positive, Hyperglycemia: positive)
Received: 04 Jul 2024; Accepted: 01 Sep 2025.
Copyright: © 2025 Zhang, Zhang, Li, Z, You, Su, Zheng and Suyu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yulong Zhang, Fujian Medical University, Fuzhou, China
Li Suyu, Fujian Medical University, Fuzhou, China
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