SYSTEMATIC REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1456754
This article is part of the Research TopicOvarian Aging: Pathophysiology and Recent Development of Maintaining Ovarian Reserve, Volume IVView all 6 articles
Rodent models of functional hypothalamic amenorrhea: a systematic scoping review
Provisionally accepted
- 1College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea
- 2College of Korean medicine, Gachon university, Seongnam, Republic of Korea
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Introduction: Functional hypothalamic amenorrhea (FHA) is a complex clinical condition crucial to understand and treat due to its intricate etiology, difficulties in applying standard treatments, and significant long-term health effects. This study aimed to summarize and analyze the current research methodologies and findings from rodent models of FHA to provide insights for future investigations.A literature search was conducted on EMBASE and MEDLINE up to September 23, 2022, using predefined search terms to target FHA-related studies in rodent models. This review focused on experimental studies involving rodent models of FHA, including related nonorganic disorders, such as primary ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS). Data were independently collected by researchers, detailing animal models, FHA induction methods, experimental outcomes, and mechanistic exploration, with a synthesis of results comparing FHA with POI and PCOS.Results: Thirty articles (9 on FHA, 14 on POI, and 7 on PCOS) were analyzed, revealing diverse FHA induction methods, including dietary interventions and exercise, inconsistencies in estrous cycle monitoring, and varied focuses in mechanistic investigation. Some studies have emphasized hypothalamic-pituitary-adrenal axis dysfunction, whereas others have investigated ovarian abnormalities. Comparative analyses of POI and PCOS models identified research gaps and suggested future research directions. Conclusions: The incorporation of consistent estrous cycle monitoring and biomarker measurements is crucial for the advancement of FHA research. Future studies should comprehensively investigate hormonal changes and explore potential therapeutic targets for ovarian inflammation and androgen involvement.
Keywords: Functional hypothalamic amenorrhea, rodent models, Reproductive disorders, Primary Ovarian Insufficiency, Polycystic Ovary Syndrome
Received: 02 Aug 2024; Accepted: 02 May 2025.
Copyright: © 2025 Min, Kim, Park, Kang and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Byoung-Soo Kim, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.