ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1470473
This article is part of the Research TopicContinuous Glucose Monitoring: Beyond Diabetes ManagementView all 12 articles
To assess the impact of individualized strategy and continuous glucose monitoring (CGM) on glycemic control and mental health in pregnant women with diabetes
Provisionally accepted
- 1First Affiliated Hospital, Dalian Medical University, Dalian, China
- 2Dalian Neusoft University of Information, Dalian, Liaoning Province, China
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Objective: To assess the impact of individualized strategy and continuous glucose monitoring (CGM) on glycemic control and mental health(anxiety, depression, pregnancy-related anxiety and diabetes specific quality of life during pregnancy) in patients with diabetes in pregnancy (DIP).Methods: In this study, 80 pregnant women diagnosed with type 2 diabetes mellitus (T2DM) complicated with pregnancy or gestational diabetes mellitus (GDM) were enrolled. Participants were randomly assigned to either CGM group or self-monitoring of blood glucose (SMBG) group. Blood glucose was regularly monitored for 14 days to guide and adjust hypoglycemic treatment (lifestyle or hypoglycemic agents) of the patients in time. Baseline characteristics were collected after enrollment. Self-rating anxiety scale (SAS), self-rating depression scale (SDS), pregnancy-related anxiety questionnaire (PAQ), diabetes specific quality of life scale (DSQL) were used to evaluate the anxiety, depression, pregnancy-related anxiety and quality of life. Glycemic parameters and scale scores were collected before and after individualized strategy.Results:FBG and 2hPBG significantly decreased post-intervention in both groups (P<0.001). In the CGM group, the scores of SAS (39.59±7.10 vs 37.15±6.28), PAQ (24.15±6.45 vs 22.59±5.65) and DSQL (47.44±9.01 vs 43.20±9.00) after individualized strategy were significantly lower than those before individualized strategy (P<0.05). The SAS scale scores and PAQ scale scores were positively correlated with blood glucose levels (P<0.05).4The individualized strategy encompasses an insulin titration protocol guided by CGM, coupled with structured lifestyle modifications that address dietary patterns，physical activity and more，combined with short-term glucose monitoring can exert a positive effect on glycemic improvement in the short term and meet the requirements of glycemic control in pregnancy, which has important clinical significance.The combined use of individualized strategy and CGM improves glycemic control and may have protective effects on psychological well-being.
Keywords: Clinical trial registration number: ChiCTR2200060719 diabetes in pregnancy, gestational diabetes mellitus, Continuous glucose monitoring, Anxiety, Depression, Quality of Life
Received: 25 Jul 2024; Accepted: 26 May 2025.
Copyright: © 2025 Liu, Chen, Wang, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dan Liu, First Affiliated Hospital, Dalian Medical University, Dalian, China
Na Li, First Affiliated Hospital, Dalian Medical University, Dalian, China
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