The association of diabetic retinopathy and diabetic kidney disease in patients with type 2 diabetes mellitus: a prospective observational research

Yutong WuZhuomin HongXiangxia Luo^*

• Gansu University of Chinese Medicine, Lanzhou, China

Background: Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are two prevalent diabetic complications, significantly influencing global health and quality of life. However, little is known about their relationship in patients with type 2 diabetes mellitus (T2DM).Aim: This study aimed to investigate the relationship between DR and DKD through a prospective observational research. Patients and methods: T2DM patients were recruited from November 2020 to November 2022. 223 T2DM patients were finally enrolled. Additionally, 50 healthy examinees were included as the control group. Diagnostic and staging criteria for DR referred to previously established standards. DKD was assessed using serum levels of cystatin C (CysC), β2-microglobulin (β2-MG) and homocysteine (Hcy). The traditional Chinese medicine (TCM) syndrome differentiation standards were based on the TCM Diagnosis and Treatment Standards for diabetes Retinopathy issued by the diabetes Branch of the Chinese Society of Traditional Chinese Medicine in 2011. Outcomes of interest were measured at baseline. Results: This study included 223 T2DM patients, aged from 32 to 78 years. According to DR staging, patients were further categorized into four T2DM subgroups, namely T2DM without DR, T2DM with light or moderate no proliferative DR (lmNPDR), T2DM with heavy no proliferative DR (hNPDR) and T2DM with proliferative DR (PDR). 154 (154/223, 69.06%) were diagnosed with DR. As DR severity increased, levels of three DKD indicators presented a significant upward trend compared to the control group, except for Hcy in the PDR subgroup. Spearman correlation analysis revealed significant associations between each DKD indicator and the T2DM subgroups, with Hcy for rs=0.223, P=0.001, CysC for rs=0.452, P<0.001 and β2-MG for rs=0.564, P<0.001. Three TCM syndrome types were identified. For four T2DM subgroups, the proportion of qi-yin deficiency increased with reducing DR severity, whereas the proportion of yin-yang deficiency increased with increasing DR severity. Three DKD indicators exhibited statistically significant difference between deficiency of liver and kidney or yin-yang deficiency and qi-yin deficiency, except for Hcy in yin-yang deficiency. Conclusion: This study suggests a potential association between DR and DKD, and provides evidence that the incidence of qi-yin deficiency and yin-yang deficiency exhibits opposite trends with respect to DR severity.