ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1486197
This article is part of the Research TopicRecent Advances in Gestational Diabetes: Diagnosis, Treatment and PreventionView all 5 articles
Decreased Risks of Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
Provisionally accepted
- The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
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Aim: To investigate the association of pancreatic duodenal homeobox-1 (PDX1) in early pregnancy with the risks of gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.Methods: A total of 231 pregnant women were recruited at their initial antenatal care visit during 8-12 gestational weeks in this study. The 75g OGTT was performed during 24-28 gestational weeks. Blood samples were collected to measure PDX1 levels. Participants were followed throughout their pregnancy to monitor for the development of GD and adverse pregnancy outcomes. The odds ratio (OR) was used to assess the risks of GD and adverse pregnancy outcomes.Results: Pregnant women in the GDM group had higher levels of HOMA-IR and TyG index, and lower PDX1 levels both in early and mid-pregnancy (P<0.05), but had lower HOMA-β levels only in mid-pregnancy (P<0.05). PDX1 in early pregnancy was negatively correlated with FPG, 2h PG, HOMA-IR, and TyG, while positively correlated with HOMA-β in mid-pregnancy (P<0.05). The adjusted analysis showed that elevated PDX1 levels in early pregnancy were associated with reduced risks of GDM (aOR 0.287, 95%CI 0.130-0.636, P=0.002), macrosomia (OR 0.249, 95%CI 0.076-0.811, P=0.021) and composite adverse pregnancy outcomes (OR 0.496, 95%CI 0.256-0.960, P=0.037).Elevated PDX1 in early pregnancy was associated with decreased risks of GDM and adverse pregnancy outcomes.
Keywords: Pancreatic duodenal homeobox-1, gestational diabetes mellitus, Adverse pregnancy outcomes, early pregnancy, Mid-pregnancy
Received: 25 Aug 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Zhang, Zhang, Dong, Liu, Wei, Li and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kai Li, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
Yu Lu, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
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