ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1486633
This article is part of the Research TopicLifestyle and Environmental Factors and Human FertilityView all 20 articles
The association between season and meteorological factors on clinical outcomes after fresh embryo transfer: a cohort study from Central Plains, China
Provisionally accepted
- First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To investigate whether seasonal variations and meteorological factors influence pregnancy outcomes in women undergoing in vitro fertilization /Intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) treatment. Materials and methods: We conducted a retrospective cohort study of women who underwent IVF/ICIS-ET for the first time at the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 1, 2011, to December 1, 2021. A total of 24420 cycles were collected. They were divided into four groups according to the oocyte retrieval date. The main outcome measures were clinical pregnancy rate and live birth rate. Binary logistic regression was used to explore the factors affecting clinical pregnancy rate and live birth rate.Results: In this study, the live birth rate of cycles with oocyte retrieval performed in summer was significantly higher than those in spring, autumn, and winter (61.24% [4859/7934] vs. 59.09% [3074/5202] vs. 58.89% [3676/6242] vs. 57.70% [2909/5042]; P<0.001), with the summer group also exhibiting the lowest abortion rate among the four seasons. Notably, despite these differences, no statistically significant variations were observed in biochemical pregnancy rates or clinical pregnancy rates across the groups (P>0.05). Taking spring as the reference, the live birth rate in summer was higher (aOR=1.079,95% CI:1.004-1.160), and the abortion rate was lower (aOR = 0.841,95% CI: 0.746-0.948). The live birth rate and abortion rate in autumn and winter were not significantly different from spring. Multivariate logistic regression analysis showed higher daily average temperature, and humidity at the time of oocyte retrieval increased the live birth rate (OR = 1.005, 95% CI = 1.002-1.007; OR = 1.004, 95% CI = 1.001-1.006).In women who undergo IVF/ICSI treatment, the season、 ambient temperature, and humidity on the date of the oocyte retrieval may impact embryo development and live birth.
Keywords: Art, Season, temperature, live birth rate, Clinical pregnancy rate
Received: 26 Aug 2024; Accepted: 29 Apr 2025.
Copyright: © 2025 Li, Li, Li, Ma and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gang Li, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.