ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1491259
This article is part of the Research TopicLifestyle and Environmental Factors and Human FertilityView all 22 articles
The impact of inoculation of inactivated COVID-19 vaccine on the outcomes of in vitro fertilization and embryo transfer: A cohort study of 1258 women from Sichuan, China
Provisionally accepted
Jiajing Wei1
Yu Qiu1,2Mei Leng1Fu-Rui Chen1,2Mei-Yu Liang1Xi Deng1Rong-Ning Ma1Jing Hei1Jesse Li- Ling3
Yan Gong1*- 1Sichuan Provincial Hospital for Women and Children, Chengdu, China
- 2Chengdu Medical College, Chengdu, Sichuan, China
- 3West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
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Objective: To assess the impact of inoculation of inactivated Coronavirus disease-2019 (COVID-19) vaccine on the outcomes of in vitro fertilization and embryo transfer (IVF-ET). Methods: From January 2021 to December 2022, patients undergoing the first cycle of IVF-ET at the Reproductive Medicine Center of Sichuan Provincial Women's and Children's Hospital were prospectively enrolled. Based on the inoculation of inactivated COVID-19 vaccines before ovarian stimulation (OS) by gonadotrophin-releasing hormone (GnRH) antagonist or agonist protocol, they were divided into vaccinated group (n = 713) and unvaccinated group (n = 545). The vaccinated group were sub-grouped based on the dose of inoculation (single dose, n = 74; double dose, n = 275; triple dose, n = 126) and the interval between the first inoculation and OS (< 3 months, n = 65; 3 ~ 6 months, n = 123; > 6 months, n = 287).The rates of mature oocyte, normal fertilization, cleavage embryo, high-quality cleavage embryo, blastocyst, high-quality blastocyst were not significantly different between the vaccinated and unvaccinated groups (P > 0.05).For fresh embryo transfer, the implantation rate (IR), clinical pregnancy rate (CPR), live birth rate (LBR), gestational age at delivery, birth weight of infants were not significantly different between the two groups (P > 0.05). The IR, CPR, LBR and birth weight of infants were not significantly different for both the dose and interval subgroups (P > 0.05).Inactivated COVID-19 vaccine may not affect the outcomes of IVF-ET.
Keywords: SARS-CoV-2, Inactivated vaccine, in vitro fertilization, Embryo Transfer, Live Birth
Received: 04 Sep 2024; Accepted: 13 May 2025.
Copyright: © 2025 Wei, Qiu, Leng, Chen, Liang, Deng, Ma, Hei, Li- Ling and Gong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Gong, Sichuan Provincial Hospital for Women and Children, Chengdu, China
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