ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1492293
A Comparative Analysis of Progestin-Primed Ovarian Stimulation Versus GnRH Antagonist Protocols Pertaining to Stimulation Parameters and Embryological Outcomes in Patients with Endometrioma
Provisionally accepted
Kubra Fazilet Boynukalin1*
Yusuf Aytaç Tohma2Meral Gultomruk1Zalihe Yarkıner3Ceren Melisa Akkaya4Sinan Ozkavukcu2Mustafa Bahceci1Gürkan Bozdağ1- 1Bahçeci Fulya IVF Center, Istanbul, Türkiye
- 2Bahçeci Ankara IVF Center, Ankara, Ankara, Türkiye
- 3Cyprus International University, Nicosia, Nicosia, Cyprus
- 4Atılım University, Ankara, Türkiye
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Research question: Do embryo parameters and live birth rates differ between patients with endometrioma undergoing freeze all strategy using GnRH antagonist or progestin-primed ovarian stimulation (PPOS)?Design: This retrospective cohort study was conducted at Bahceci Health Group from January 2021 to January 2023. Inclusion criteria were females aged 20-40 with confirmed endometriosis, using GnRH antagonist or PPOS ovarian stimulation, and opting for freezing all embryos without fresh ET. A total of 543 patients were analyzed, with primary outcome being usable embryos at cleavage stage, and secondary outcomes including distribution of embryo quality distribution, clinical pregnancy and live birth rate.Results: Whereas the median (25 th -75 th percentiles) total gonadotropin dose required during the stimulation was significantly higher (
Keywords: PPOS, endometroiosis, Endometrioma, ICSI, GnRH antagonist
Received: 06 Sep 2024; Accepted: 11 Jun 2025.
Copyright: © 2025 Boynukalin, Tohma, Gultomruk, Yarkıner, Akkaya, Ozkavukcu, Bahceci and Bozdağ. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kubra Fazilet Boynukalin, Bahçeci Fulya IVF Center, Istanbul, Türkiye
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.