ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1503667
Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study
Provisionally accepted
- 1Department of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 2Department of Pathology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangx, China
- 3The Key Laboratory of Molecular Pathology in Tumors of Guangxi Higher Education Institutions, Baise, China
- 4Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China
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Introduction: Diabetic kidney disease (DKD) is linked to immunity and inflammation. We aimed to investigate if systemic inflammatory indicators can predict mortality in DKD patients in intensive care units (ICUs) and determine potential associations between them. Methods: This study included a cohort of 840 adults with DKD in the ICU. Three systemic inflammatory indicators were evaluated by peripheral blood tests: systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR). Cox regression analysis, restricted cubic spline (RCS), and Kaplan-Meier curves were used to evaluate the associations between the inflammatory indicators and the mortality of the DKD population. Receiver operating characteristic (ROC) was employed to ascertain the predictive accuracy of varied systemic inflammatory indicators. Results:After adjusting for all covariates, Cox regression analysis showed that inflammatory indicators were all significantly positively associated with 28-day mortality (SII:
Keywords: systemic inflammatory indicators, Diabetic kidney disease, Mortality, MIMIC-IV, cohort study
Received: 04 Nov 2024; Accepted: 12 May 2025.
Copyright: © 2025 Shen, Wang, Lv, Huang, Zhang and WU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: JUN WU, Department of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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