ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1510470
This article is part of the Research TopicThe Role of Normal Blood Lipid Levels in Metabolic and Endocrine DiseasesView all articles
Association between remnant cholesterol levels and reversion to normoglycemia from prediabetes: a 5-year longitudinal cohort study of Chinese non-obese adults
Provisionally accepted
- 1Shenzhen Second People's Hospital, Shenzhen, China
- 2Huangpu People's Hospital, Zhongshan, Guangdong Province, China
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The primary objective of this study is to explore the relationship between remnant cholesterol (RC) levels and the reversion to normoglycemia in non-obese Chinese individuals with prediabetes.To achieve this goal, we conducted a retrospective cohort study involving 8,109 non-obese prediabetic participants in China, using the logistic regression model to analyze the correlation between RC and the likelihood of returning to normoglycemia.The results indicate a significant negative correlation between RC levels and reversion to normoglycemia (OR=0.49, 95% CI: 0.47-0.52). Specifically, as RC quartiles increase, the probability of reverting to normoglycemia significantly decreases, with participants in the highest quartile having a 51% lower likelihood of recovery compared to those in the lowest quartile. Furthermore, we identified a nonlinear relationship between RC and the reversion to normoglycemia, with 1.10 mmol/L established as the inflection point. When RC levels are below this threshold, decreasing RC significantly increases the likelihood of recovery. To further validate the robustness of our findings, we conducted sensitivity and subgroup analyses, all of which support the reliability of the main results.There exists a significant negative and nonlinear relationship between RC levels and the reversion to normoglycemia in non-obese Chinese prediabetic patients. This suggests that lowering RC levels may play an important role in reversion to normoglycemia from prediabetes.
Keywords: Remnant cholesterol, Reversion, Normoglycemia, prediabetes, non-obese adults
Received: 16 Oct 2024; Accepted: 14 Jul 2025.
Copyright: © 2025 Huang, Liu, Jian and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenhua Huang, Shenzhen Second People's Hospital, Shenzhen, China
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