ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1527092
A dual domain Systematic Review and Meta-Analysis of Risk Tool Accuracy to Predict Cardiovascular Morbidity in Prehypertension and Diabetic Morbidity in Prediabetes
Provisionally accepted
- Imperial College London, London, United Kingdom
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Objective: Health forecasting predicts population trends through risk prediction algorithms which can estimate the risk of future disease developing. Screening algorithms can systematically identify patients with a high probability of undiagnosed diseases for diagnostic testing. We describe a dual domain systematic review and meta-analysis of the accuracy of available risk tools to (1) predict prehypertensive deterioration to cardiovascular morbidity, & (2) predict prediabetes deterioration to diabetic morbidity. Materials and Methods: The primary outcome was the accuracy of the risk scores, and the secondary outcomes were the reporting quality and risk of bias. The dual domain systematic review included studies involving risk tools for (1) prehypertensive adults to predict cardiovascular morbidity (including hypertension, stroke and coronary heart disease) and (2) prediabetic adults to predict diabetic morbidity (including Type 2 Diabetes and end organ damage, such as diabetic nephropathy). Following PROSPERO registration (IDs 425686 & 425683), searches were conducted in PubMed, MEDLINE and Google Scholar. Results: Accuracy of risk prediction in prehypertension and prediabetes was high: the pooled C statistic for All Cause Cardiovascular Disease was 0.77 (CI 0.71, 0.84) and the pooled Sensitivity for All Cause Diabetic Disease Spectrum risk was 0.68 (CI 0.65, 0.7). However, we found high risk of bias, with inconsistent reporting in both prehypertension and prediabetes papers. Discussion: We propose nine recommendations for policymakers and commissioners, organised under an "A to I" framework. Conclusion: We found that predictive performance was generally accurate. However, there remain limitations due to methodological inconsistency, such as timeframe, which undermines comparison.
Keywords: Prehypertension, prediabetes, diabetic morbidity, cardiovascular disease, screening
Received: 12 Nov 2024; Accepted: 23 Jun 2025.
Copyright: © 2025 Waldock, Tekkis, Zhang and Ashrafian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hutan Ashrafian, Imperial College London, London, United Kingdom
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