REVIEW article
Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1529231
This article is part of the Research TopicNaturally Occurring Compounds and Their Applications in Endocrinology: Mechanisms, Therapeutic Potential and Clinical ApplicationsView all 6 articles
Effect and mechanism of resveratrol against polycystic ovary syndrome: a review
Provisionally accepted
- 1Heilongjiang University of Chinese Medicine, Harbin, China
- 2Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder characterized by significant clinical heterogeneity. The etiology of PCOS remains elusive, though it is closely linked to genetic, metabolic, endocrine, and environmental determinants.Resveratrol, a natural polyphenol, has garnered considerable interest due to its diverse biological activities. While resveratrol has been shown to ameliorate disorders in glucose, lipid, and endocrine metabolism associated with PCOS, the precise underlying mechanisms remain unclear. This narrative review aims to explore the potential mechanisms through which resveratrol operates, considering the multifaceted pathological pathways of PCOS, thereby offering insights for clinical applications and drug development.
Keywords: Polycystic Ovary Syndrome, resveratrol, Metabolism, Mechanism, Treatment
Received: 13 Feb 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Shi, Wang, Chang, Lu, Guan and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoke Wu, Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.