ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1535540
Association between new anthropometric indices and osteoporosis in Chinese postmenopausal women-Retrospective study based on hospitalized patients in China
Provisionally accepted
- Department of Endocrinology, International Hospital, Peking University, Beijing, Beijing Municipality, China
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Objective: This study aimed to investigate the correlation between new anthropometric indicators and osteoporosis in postmenopausal women, evaluate whether these indicators can be used for the screening of osteoporosis in postmenopausal women, and provide evidence for the prevention of osteoporosis and fractures in these patients. Methods: This study retrospectively analyzed 470 females hospitalized in the Department of Endocrinology of Peking University International Hospital between January 2017 and August 2022. According to the bone mineral density (BMD) results, the subjects were divided into two groups: the normal group and the osteoporosis group. Results: (1) Compared with the normal group, the women in the OP group were older, the levels of BMD were lower, and the levels of 25(OH)D were lower, with all the differences being statistically significant (p<0.05). The body shape index (ABSI), Chinese visceral fat index (CVAI), abdominal volume index (AVI), and body roundness index (BRI) were significantly higher, and the body mass index (BMI) was significantly lower in the Osteoporosis (OP) group than in the normal group (all p<0.05). (2) CVAI was negatively correlated with hip BMD and lumbar spine BMD (r=-0.35, p<0.05; r=-0.20, p<0.05). BRI was negatively correlated with hip and lumbar spine BMD (r=-0.37, p<0.05; r=-0.20, p<0.05). (3) After adjusting age, blood pressure (BP), blood glucose, blood lipids, estimated Glomerular Filtration Rate (eGFR) and Ca levels, high levels of CVAI, AVI and BRI were independent risk factors for OP (OR=4.27, 95%CI 2.49, 7.33; OR=2.08, 95%CI 1.23, 3.51; OR=6.11, 95% CI 3.39, 11.01). (4) The model for predicting the risk of OP using anthropometric indicators showed that the AUCs ranked CVAI > BRI > ABSI > AVI = BMI > lipid accumulation index (LAP) > waist-to-hip ratio (WHR) > waist-to-height ratio (WHtR). Conclusion: This clinical study showed that new anthropometric indicators are associated with osteoporosis in postmenopausal women. It is necessary to pay attention to CVAI, BRI, AVI, and other anthropometric indicators in postmenopau
Keywords: Osteoporosis, Lipid accumulation product, Abdominal volume index, Body roundness index, Chinese visceral adiposity index
Received: 27 Nov 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Zhao, sun, xin and XIAOMEI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: ZHANG XIAOMEI, Department of Endocrinology, International Hospital, Peking University, Beijing, 100871, Beijing Municipality, China
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