REVIEW article
Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1536155
The intratumor microbiota and thyroid cancer: a review
Provisionally accepted
- Second Affiliated Hospital of Jilin University, Changchun, China
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Thyroid cancer is a prevalent malignancy with a rising global incidence, driven by factors such as genetic mutations, environmental influences, and gender differences.Despite advancements in diagnostic techniques and treatments, effective therapies for advanced or iodine-refractory thyroid cancer remain limited. Recent discoveries have challenged the long-held belief that tumors are sterile, revealing the presence of intratumor microbiota in various cancers. Intratumor microbiota significantly impact cancer development, immune reactions, and the effectiveness of treatments. This review examines the emerging evidence of intratumor microbiota in thyroid cancer, emphasizing their potential roles in tumor development. We also examine the origins and diversity of these microbial communities and investigate the mechanisms through which they might affect thyroid cancer progression. Understanding the complex interactions between intratumor microbiota and thyroid cancer could inform the development of novel diagnostic tools and therapeutic strategies to improve patient outcomes.
Keywords: intratumor microbiota, thyroid cancer, tumorigenesis, mechanisms, Tumor Microenvironment
Received: 29 Nov 2024; Accepted: 12 Jun 2025.
Copyright: © 2025 Liu, Xiong, Hao, Shi and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shan Liu, Second Affiliated Hospital of Jilin University, Changchun, China
Long yin Zhao, Second Affiliated Hospital of Jilin University, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.