Impact of hyperglycaemia and antidiabetic medication on pancreatic uptake on [ 68 Ga]Ga-DOTATOC PET/CT

Sophie Carina Kunte^1,2*Thorsten Siegmund³Maximilian Tiling¹Lukas Ostermair⁴Lena Maria Unterrainer^1,2,5Marily Theodoropoulou⁴Martin Reincke⁴Friederike Völter^1,4

• ¹Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Bavaria, Germany
• ²Bayerisches Zentrum für Krebsforschung (BZKF), partner site Munich, Munich, Bavaria, Germany
• ³Division for Endocrinology, Diabetology and Metabolism, Isar Clinic Munich, Munich, Germany
• ⁴Department of Medicine IV, Endocrinology, Diabetes and Metabolism LMU University Hospital, LMU Munich, Munich, Germany
• ⁵David Geffen School of Medicine at UCLA, Ahmanson Translational Theranostics Division, UCLA Health System, Los Angeles, California, United States

Positron-emission-tomography-(PET)/computed-tomography-(CT) using somatostatin-receptor-(SSTR)-binding radioligands is well established in the imaging of neuroendocrine tumors (NETs). SSTRs are expressed in NETs and endocrine and exocrine tissues, e.g. pancreas, where somatostatin binding to SST2 and SST5 inhibits glucagon and insulin secretion. Pancreatic background activity on SSTR-PET varies widely and is increased in up to 45% of cases. High uptake in the processus uncinatus can obscure NETs or cause false positives. The determinants of elevated pancreatic activity on SSTR-PET remain unclear, prompting investigation into the association between pancreatic radioligand uptake and diabetic status.All patients with non-pancreatic NETs undergoing [68Ga]Ga-DOTATOC-PET/CT at LMU clinic with available HbA1c were included. Patients were grouped: without glucose metabolism disorder (HbA1c 4.0-5.6%), prediabetes (HbA1c 5.7-6.4%), type 2 diabetes mellitus. Pancreatic volume and tracer uptake were assessed, with correlation and regression analyses between SSTR expression and HbA1c. The study included 40 patients (54 scans; n=22: normal glucose metabolism, n=20: prediabetes, n=12: diabetes; n=11: antidiabetic medication (AM)). Patients with normal glucose homeostasis showed increased tracer-uptake than those with impaired glucose metabolism (p=0.033; p=0.009). Correlation analysis revealed a significant negative correlation of HbA1c and SUVmax in patients without AM (r2=0.267; p<0.001). Multiple linear regression analysis with AM as a covariate revealed a significant association between HbA1c and SUVmax (r2=0.667; CI -0.371 to -0.135; p<0.001), AM was a significant covariate (CI 1.393 to 2.120; p<0.001). The association between HbA1c and SUVmean showed a trend (p=0.061) but no statistical significance.Our findings indicate a significant association between pancreatic [68Ga]Ga-DOTATOC-uptake and glucose metabolism, suggesting that [68Ga]Ga-DOTATOC-PET/CT sensitivity for detecting pancreatic NETs may be affected by individual glucose homeostasis.