ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1539114
This article is part of the Research TopicRe-visiting Risk Factors for Cardiometabolic Diseases: Towards a New Epidemiological FrontierView all 31 articles
Fibrinogen-to-albumin ratio predicts Mortality in patients with Diabetes Mellitus and atherosclerotic cardiovascular disease
Provisionally accepted
- 1Capital Medical University, Beijing, Beijing Municipality, China
- 2Beijing Jishuitan Hospital, Beijing, Beijing Municipality, China
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Background: Circulating fibrinogen-to-albumin ratio (FAR) has been proposed as a novel inflammatory biomarker in patients with heart failure and malignant tumor.However, the prospective association in patients with atherosclerotic cardiovascular disease (ASCVD) remains to be investigated.: The trial enrolled 821 patients with ASCVD from United States National Health and Nutrition Examination Survey from 1999-2002, with mortality follow-up through December 31st, 2019. Participants were divided into high-level FAR (FAR_H) and low-level FAR (FAR_L) groups. Kaplan-Meier and Cox proportional risk models were used to investigate the relationship between FAR and all-cause mortality in middle-aged and older persons with diabetes mellitus (DM). Results: During the median follow-up time of 15.6 years, 608 (weighted, 74.1%)ASCVD patients developed mortality. The incidence of mortality differed significantly between the FAR groups in patients with or without DM. Compared with FAR_L group, the FAR_H group has increased 90% mortality in the ASCVD patients with DM (HR = 1.90, 95%CI 1.22 -3.00; P = 0.005). Moreover, the FAR and DM have a significant interaction (P = 0.016) in the ASCVD patients.In this prospective cohort study, a higher level of FAR was independently associated with 15-year mortality among ASCVD patients with DM.The combination of FAR and DM in ASCVD patients may aid in risk stratification and prognosis.
Keywords: fibrinogen-to-albumin ratio, Atherosclerotic cardiovascular disease, prognosis, Mortality, Diabetes Mellitus
Received: 03 Dec 2024; Accepted: 13 May 2025.
Copyright: © 2025 Yu, Fan, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Liu, Beijing Jishuitan Hospital, Beijing, 100035, Beijing Municipality, China
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