ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1540558
Atherogenic index of plasma is associated with vertebral fracture: a longitudinal study
Provisionally accepted
- Shanghai Jiading District Central Hospital, Shanghai, China
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Purpose: The atherogenic index of plasma (AIP), recognized as a marker of atherosclerosis, which also has a profound impact on bone metabolism. However, research exploring the association between the AIP and the probability of vertebral fractures in populations is still relatively scarce. The study aims to evaluate the association between the AIP and vertebral fractures probability in individuals in a longitudinal study.Patients and Methods: A total of 1395 subjects who were older than 55 years and underwent CT scans for lung cancer screening between July 2019 and July 2021 were enrolled and followed up for a duration ranging from 8 months to 6 years. Among them, 91 individuals experienced new vertebral fractures. Participants were stratified into four groups based on AIP quartiles. The association between the AIP and vertebral fractures probability was then assessed by cox proportional hazards model.Results: The incidence of vertebral fracture decreased with increasing AIP (p for trend = 0.001). Kaplan-Meier survival analysis indicated that vertebral fractures were more likely to occur in patients with low levels of AIP (log-rank, all P < 0.05). Multivariate Cox regression analysis showed that AIP was negatively associated with the probability of vertebral fractures even after accounting for confounding factors (adjusted hazard ratio (aHR) = 0.27, 95%CI = 0.10-0.71 for continuous AIP; aHR = 0.48, 95%CI = 0.26-0.90 for Q2; aHR = 0.41, 95%CI = 0.19-0.88 for Q4, respectively). Subgroup analysis showed that such associations were mainly observed in male subjects. Restricted cubic splines further showed that the probability of vertebral fracture decreased with the increasing of AIP after adjusting with confounders in overall population and men, but not in women.Conclusion: Our study demonstrated a strong association between the AIP and the probability of vertebral fracture. Low AIP may be an associated factor of vertebral fracture.
Keywords: , atherogenic index of plasma, Fracture, Spine, longitudinal study, general population
Received: 06 Dec 2024; Accepted: 12 May 2025.
Copyright: © 2025 Zhang, Xie, Yin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Yin, Shanghai Jiading District Central Hospital, Shanghai, China
Xin-Feng Li, Shanghai Jiading District Central Hospital, Shanghai, China
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