ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1541388
Correlation between serum-25 hydroxyvitamin D levels and peripheral neuropathy in type 2 diabetes mellitus
Provisionally accepted
- 1Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China
- 2Fujian Medical University, Fuzhou, Fujian Province, China
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Objective: To investigate the correlation between serum 25-hydroxyvitamin D (25[OH]D) levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) and to evaluate its predictive value for DPN. Methods: Participants were divided into three groups based on 25(OH)D levels: deficient, insufficient, and normal. The relationship between 25(OH)D and DPN, as well as the correlation of 25(OH)D and DPN with various indicators, were analyzed.Results: Compared to the non-DPN group (NDPN), the DPN group had significantly lower levels of 25(OH)D3 (22.10 ± 0.77 ng/mL vs. 24.45 ± 0.66 ng/mL) and total 25(OH)D (23.12 ± 0.74 ng/mL vs. 25.68 ± 0.67 ng/mL). In addition, significant differences were observed in body mass index (BMI), resting heart rate (RHR), triglyceride (TG), free triiodothyronine (FT3), and blood urea nitrogen (BUN) between the two groups (P <0.05). Multivariate analysis identified 25(OH)D3, total 25(OH)D, FT3, BMI, and RHR as risk factors for DPN. The receiver operating characteristic (ROC) curve analysis revealed that the optimal cutoff value for 25(OH)D3 in predicting DPN in T2DM was 18.85 ng/mL (area under the curve [AUC] 0.76, 95% confidence interval [CI] 0.697-8.823), while the optimal cutoff for total 25(OH)D was 19.94 ng/mL(AUC 0.765, 95% CI 0.703-0.828).Serum 25(OH)D levels can serve as a simple and effective screening tool to predict the occurrence of DPN in patients with T2DM.provide valuable insights for the prevention and treatment of DPN in clinical practice.We collected clinical data from patients treated in the Second
Keywords: Serum 25-hydroxyvitamin D, Liquid chromatography-tandem mass spectrometry ( LC-MS / MS ), type 2 diabetes mellitus, DPN, NDPN
Received: 07 Dec 2024; Accepted: 14 May 2025.
Copyright: © 2025 Senzhen, chen, chen, huang, zheng and yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: nuoqi chen, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China
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