ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1541421
This article is part of the Research TopicLiver Diseases – From Pathophysiology to New Treatment OptionsView all 6 articles
Positive correlations between TyG and TyG-BMI indices and the risk of NAFLD and degree of liver fibrosis in patients undergoing PCI
Provisionally accepted
- 1School of Medicine, Nankai University, Tianjin, China
- 2Tianjin Medical University, Tianjin, Tianjin Municipality, China
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Background: We aim to investigate the association between TyG(Triglyceride-Glucose index) and TyG-BMI(Triglyceride-Glucose-Body Mass Index) indices and the risk of non-alcoholic fatty liver disease (NAFLD) in patients undergoing percutaneous coronary intervention (PCI), an area where their predictive value is currently unclear, despite their established link to insulin resistance, metabolic syndrome, and cardiovascular disease. Methods: In this cross-sectional study, 776 patients who underwent coronary angiography and PCI were categorized into NAFLD+PCI and PCI groups based on abdominal ultrasound. They were further classified by TyG and TyG-BMI indices. Continuous variables were compared using ANOVA, Wilcoxon-Mann-Whitney, or t-tests, while categorical variables were analyzed with χ² or Fisher exact tests. Logistic regression identified independent factors for NAFLD in PCI patients. ROC curves evaluated the predictive efficacy of TyG and TyG-BMI for NAFLD. Linear correlation and multiple linear regression assessed relationships among NAFLD fibrosis score (NFS), TyG, and TyG-BMI. Results: Among 776 patients, NAFLD was detected in 305. After adjusting for age, smoking, hypertension, diabetes, sex, and cardiovascular disease, multivariate logistic regression showed the TyG index was a significant risk factor for NAFLD in PCI patients (OR=2.04; 95% CI, 1.62-2.55; P < 0.001). Similarly, the TyG-BMI index, total cholesterol, triglycerides, LDL cholesterol, fasting blood glucose, and BMI were associated with increased NAFLD risk. Each unit increase in the TyG index raised the NAFLD risk by 2.63-fold (OR=2.63; 95% CI, 1.78-3.8; P<0.001), and each unit increase in the TyG-BMI index by 3.80-fold (OR=3.80; 95% CI, 2.55-5.68; P < 0.001). Multivariate linear regression indicated that in the PCI-NAFLD group, each unit increase in the TyG index increased the NFS value by 0.247 (β = 0.247; 95% CI, 0.19-0.45; P < 0.001), and each unit increase in the TyG-BMI index increased the NFS value by 0.344 (β = 0.344; 95% CI, 0.28-0.59; P < 0.001). Conclusions: The TyG index and TyG-BMI were positively associated with the risk of NAFLD in patients treated with PCI, reflecting the severity of liver fibrosis.
Keywords: Non-alcoholic fatty liver disease, PCI, TyG, TyG-BMI, Insulin Resistance
Received: 07 Dec 2024; Accepted: 17 Sep 2025.
Copyright: © 2025 Chen, Wang, Du, Sun, Song and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chengzhi Lu, 5020200072@nankai.edu.cn
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