ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1542190
This article is part of the Research TopicScreening Remnant Lipid Markers in Cardiometabolic DiseasesView all 15 articles
Correlation analysis of ApoB and TyG index levels with residual cardiovascular risk in patients with acute myocardial infarction
Provisionally accepted
- 1The Affiliated Hospital of Qingdao University, Qingdao, China
- 2Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong Province, China
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Background Low-density lipoprotein cholesterol (LDL-C) has now been the primary target for lipid-lowering therapy in the European and US guidelines for the management of dyslipidemia, with increasing interest in apolipoprotein B (ApoB) as a secondary target. The relationship between ApoB and the severity of acute myocardial infarction as well as residual risk still needs to be further determined. Coronary atherosclerosis occurs as a result of a complex set of factors, and there is a strong relationship between insulin resistance and cardiovascular disease. In contrast, there are limited studies on the relationship between TyG index (triglyceride glucose index), an indicator of insulin resistance, and cardiovascular disease. The purpose of this study was to investigate the value of ApoB and TyG index in assessing the severity of myocardial infarction and predicting prognosis. Conclusions ApoB is an independent risk factor for major adverse cardiovascular events (MACE) following myocardial infarction. Elevated ApoB levels are more advantageous than elevated LDL-C levels in assessing the severity of coronary artery stenosis in myocardial infarction patients and predicting residual risk after myocardial infarction. Therefore, in patients with acute myocardial infarction, ApoB can be considered to guide further intensive treatment. However, the TyG index did not demonstrate a significant advantage in predicting cardiovascular residual risk in this study.
Keywords: ApoB, LDL-C, TyG index, acute myocardial infarction, Coronary atherosclerosis, Residual Risk, Adverse cardiovascular events
Received: 09 Dec 2024; Accepted: 13 Aug 2025.
Copyright: © 2025 Wang, Guo, Wang, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianmin Yang, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong Province, China
Peng Li, The Affiliated Hospital of Qingdao University, Qingdao, China
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