REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1544944
Progress in Understanding the Role and Mechanism of miRNAs in Osteoporosis
Provisionally accepted
- Shandong University of Traditional Chinese Medicine, Jinan, China
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Osteoporosis is a systemic metabolic disorder characterized by compromised bone strength and increased fracture risk. Exosomes, extracellular vesicles measuring 40-160 nm in diameter, are critical mediators of intercellular communication. Among their bioactive components, microRNAs (miRNAs) have garnered attention for their role in the pathogenesis of Osteoporosis. Through complementary binding to the 3′ untranslated regions of target genes, miRNAs regulate key processes such as bone formation, bone resorption, angiogenesis, and bone immunity. This review provides a comprehensive summary of the regulatory roles and underlying mechanisms of miRNAs in osteoporosis, offering insights into potential therapeutic strategies.
Keywords: Osteoporosis, Bone Remodeling, miRNAs, Mechanism, Exosomes
Received: 20 Feb 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Meng, Yang and Huaxin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feifei Meng, Shandong University of Traditional Chinese Medicine, Jinan, China
Wang Huaxin, Shandong University of Traditional Chinese Medicine, Jinan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.