CASE REPORT article
Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1545449
Case Report:Effect of testicular adenomatoid tumors on testicular endocrine function in children
Provisionally accepted
- Ningbo Women and Children's Hospital, Ningbo, China
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Adenomatoid tumors, rare benign mesothelial neoplasms primarily involving the reproductive tract, account for 30% of paratesticular masses and predominantly localize to the epididymal head. Although typically diagnosed in adults (mean age: 33 years), pediatric cases are exceptionally rare. Conservative excision with testicular preservation is optimal, yet diagnostic ambiguity often leads to unnecessary orchidectomy.A 5.2-year-old boy presented with asymptomatic left testicular enlargement. MRI identified a 13 × 14 mm heterogeneous mass on the lateral testis.Intraoperative frozen-section analysis suggested benign/low-grade malignancy, confirmed postoperatively as a parenchymal adenomatoid tumor via immunohistochemistry.A 5-year prospective study assessed testicular function through serial measurements of serum hormones (FSH, LH, testosterone, inhibin B, anti-Müllerian hormone) and bilateral testicular volume (TV). Our findings:Left TV exceeded age-adjusted norms by 2.1-fold (4.2 mL vs. 2.0 mL), contrasting with right TV at 0.5× mean (1.0 mL).AMH declined to a nadir (2.1ng/mL) at 48 months, recovering to 3.8 ng/mL by 60 months.INHB reached minimal levels (45pg/mL) at 6 months post-resection, peaking at 128 pg/mL by study endpoint.FSH (1.2-1.5 IU/L) and testosterone (0.15-0.18ng/mL) remained prepubertal, while LH(0.3-0.5IU/L) persisted near lower normative limits.This study demonstrates the progressive decline of Sertoli cell function in pediatric adenomatoid tumor survivors, detectable through longitudinal monitoring of INHB, AMH, and TV. The 2.1-fold compensatory hypertrophy in the affected testis suggests adaptive mechanisms requiring further 3 investigation. Conservative resection guided by frozen-section analysis prevents orchidectomy, while biomarker surveillance enables early detection of testicular dysfunction for timely intervention.
Keywords: Adenomatoid Tumor, testis function, Adolescents Child, serum inhibin B, serum AMH
Received: 15 Dec 2024; Accepted: 30 Apr 2025.
Copyright: © 2025 Li, Zhao, Chen, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Li, Ningbo Women and Children's Hospital, Ningbo, China
Hehe Chen, Ningbo Women and Children's Hospital, Ningbo, China
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