ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1545789
This article is part of the Research TopicA Lifecourse Perspective on Polycystic Ovary Syndrome (PCOS): Bridging Gaps in Research and PracticeView all 19 articles
Exploring the Potential Association and Experimental Validation of Disrupted Circadian Rhythms with Polycystic Ovary Syndrome via Meta-analysis and Bioinformatics: A Possible Pathogenic Mechanism
Provisionally accepted
Wenjia Li1
Guanmei Zhang2
Yixuan Wang1*
Yue Fang2
Siyi Wu2Xiaobo Song2Lushan Zhou2Lei Lei1Chenye Wang1
Caifei Ding1*- 1Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, China
- 2Zhejiang Chinese Medical University, Hangzhou, China
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Background: Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of this connection remains unclear. The aim of this study was to explore further links between circadian rhythm and PCOS and to identify potential mediators of the pathogenesis of PCOS. Method: We analyzed the available data on PCOS and circadian rhythm disorders.Consequently, we identified potential transcription factors (NPAS2, INSIG1, H3F3B, SCML1) through bioinformatics and verified them in a well-established PCOS mouse model. Results: Luteinizing hormone (LH), testosterone (T), and melatonin (ML) exhibited substantial changes in the PCOS patients compared to healthy controls, with ML serving as a crucial biomarker in circadian rhythms. PCR results from ovarian tissues demonstrated altered expression of circadian core oscillator in the PCOS mouse model, with NPAS2 expression aligning with the bioinformatics analysis trend. We used quercetin (QUE) as a treatment and observed that it improved the disturbed expression of circadian core oscillations. Conclusion: Our research revealed the correlation between circadian rhythm disruptions and PCOS, identified potential targets, and provided unique insights into the pathogenesis of circadian rhythm-related PCOS. The improvement of circadian core oscillations in the QUE group offers a novel strategy for the treatment of PCOS.
Keywords: Polycystic Ovary Syndrome, Circadian rhythm disorder, Quercetin, Endoplasmic Reticulum, npas2, SCML1
Received: 15 Dec 2024; Accepted: 29 Apr 2025.
Copyright: © 2025 Li, Zhang, Wang, Fang, Wu, Song, Zhou, Lei, Wang and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yixuan Wang, Hangzhou Red Cross Hospital, Hangzhou, 310004, Zhejiang Province, China
Caifei Ding, Hangzhou Red Cross Hospital, Hangzhou, 310004, Zhejiang Province, China
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