REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1546512
The strategic role of lipidomics in biomarker identification and diagnosis of gynaecological diseases
Provisionally accepted
- National Medical Research Center of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai, Tianjin, China
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Lipidomics, an emerging field in medical research, has deepened our understanding of lipid metabolism, signal transduction pathways, and intercellular communication through qualitative and quantitative analyses of patient lipid profiles. It has closely linked these biological processes to the occurrence and progression of diseases, opening new avenues of research and providing new perspectives on the diagnosis, treatment, and personalized medicine of clinical diseases. Gynecological diseases have a profound impact on women’s health but often face challenges due to delayed diagnosis and inadequate treatment options. Lipids play a crucial role in regulating cell proliferation, differentiation, and signal transduction, making them significant in the occurrence and development of gynecological diseases. The technological progress in lipidomics has greatly advanced our comprehension of lipid metabolism and biochemical mechanisms in these diseases, while also offering new technical pathways for identifying potential biomarkers. Thus, this review summarized the application of lipidomics in gynecological diseases, especially those with high incidence rates such as ovarian cancer, cervical cancer, and endometriosis, to assesses its application potential in the diagnosis, prognosis monitoring, and development of new treatment strategies for gynecological diseases, and discusses its future development trends.
Keywords: lipidomics, Gynaecological diseases, diagnosis, Mass Spectrometry, Treatment, cell-cell communication
Received: 17 Dec 2024; Accepted: 01 Sep 2025.
Copyright: © 2025 Hou, Xinying, Wang, Zhang, Ma and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Ma, National Medical Research Center of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai, 300193, Tianjin, China
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