ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1547078
This article is part of the Research TopicRe-visiting Risk Factors for Cardiometabolic Diseases: Towards a New Epidemiological FrontierView all 33 articles
Assessment of left ventricular function in patients with diabetic nephropathy using two-dimensional speckle-tracking echocardiography
Provisionally accepted
- Huadong Hospital, Fudan University, Shanghai, China
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Objective: To assess cardiac function using two-dimensional speckle-tracking echocardiography (2D-STI) in diabetic nephropathy (DN) patients and investigate the relationship between albuminuria and early cardiac systolic and diastolic dysfunction, along with associated risk factors based on clinical indicators.Methods: A total of 75 patients with DN, 100 patients with diabetes mellitus(DM), and 37 healthy controls were recruited. Clinical data were collected, and conventional echocardiography as well as 2D-STI were performed on all participants.Results: 2D-STI findings revealed a significant increased occurrence rate of subclinical left ventricular systolic dysfunction [global longitudinal strain values (GLS) <18%], among diabetic patients compared to healthy controls. Furthermore, the proportion of GLS<18% occurrence was higher in the DN group compared to the DM group (p<0.001) and especially higher in the massive albuminuria group than that in the microalbuminuria group (p<0.001). The results demonstrated that albuminuria, eGFR<60 ml/min/1.73 m 2 , and total cholesterol were identified as significant risk factors for the development of subclinical left ventricular systolic insufficiency in diabetic patients. However, when considering only patients with DN and adjusting for covariates, it was found that only total cholesterol remained statistically significant (p< 0.05).The higher cholesterol levels in patients with DN are associated with a greater risk of subclinical left ventricular systolic dysfunction reflected by a decrease in GLS assayed with 2D-STI.relevance statement: GLS measured by 2D-STI combined with clinical indexes to evaluate and predict subclinical left ventricular systolic function in patients 2 with DM, providing reference for early prevention and treatment of cardiac dysfunction in patients with DN. Key points • Subclinical left ventricular systolic dysfunction assessed by GLS in DM • Cholesterol was the risk factor for subclinical left ventricular systolic insufficiency in DN • Providing early detection measures of left ventricular systolic dysfunction in DN
Keywords: diabetic nephropathy, Albuminuria, Subclinical left ventricular systolic dysfunction, GLS (global longitudinal strain), Two-dimensional speckle-tracking echocardiography
Received: 17 Dec 2024; Accepted: 30 May 2025.
Copyright: © 2025 Zhang, Jiang, Ye, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yinjia Zhang, Huadong Hospital, Fudan University, Shanghai, China
Xiaoli Zhang, Huadong Hospital, Fudan University, Shanghai, China
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