ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1553173
A Retrospective Study on LDL-C Goal Attainment in Readmitted Hypertriglyceridemia Patients: Risk Factor Analysis
Provisionally accepted
- Nanjing Medical University, Nanjing, Jiangsu Province, China
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Objective: Despite positive impacts of lipid-lowering therapies (LLTs), the low-density lipoprotein cholesterol (LDL-C) target attainment remains suboptimal. This study aimed to investigate LDL-C goal achievement per the 2023 China guideline for lipid management among rehospitalized hypertriglyceridemia patients, who had higher chances to access the knowledge associated with lipid management and treatment, and evaluate the risk factors for LDL-C.Methods: This retrospective study was performed among rehospitalized hypertriglyceridemia patients between July 2020 and May 2023. The department-specific latent class trajectory modeling was implemented to assess the longitudinal lipid profiles. The risk factors of goal attainment were evaluated using multivariate Cox regression analysis.Results: Among 8905 readmitted patients, 5045 (56.7%) had two admissions. Only 27.1% consistently achieved LDL-C targets, while 25% never did. Nearly half were eligible for LLTs, but only 25% received them. Continuous LLT use was associated with higher goal attainment (HR: 1.23 [95% CI: 1.12-1.36]). Most readmissions (92.15%) had increasing LDL-C trajectories and less odds of achieving the LDL goals at the last hospitalization. At the latest hospitalization, patients with higher atherosclerotic cardiovascular disease (ASCVD) risk had higher chances of achieving their LDL-C targets (hazard ratio 2.00 [95% CI, 1.70-2.36]).Conclusions: LDL-C control remains poor in this population. Continuous LLT use and ASCVD risk stratification are important factors for goal attainment, highlighting the need for better long-term management and closer monitoring of low-risk patients.
Keywords: low-density lipoprotein cholesterol goal, trajectory, Lipid-lowering therapy, Dyslipidemia, Retrospective study
Received: 30 Dec 2024; Accepted: 28 Jul 2025.
Copyright: © 2025 Yuan, Chadha, Abhash and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shenglan Huang, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
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