ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1559260
This article is part of the Research TopicGenetic Regulatory Mechanisms of Adaptive Changes and Pathological Damage in Extreme EnvironmentsView all articles
Research on Related Factors of Hyperuricemia in High Altitude Area Migrant Population
Provisionally accepted
- People's Liberation Army Joint Logistics Support Force 940th Hospital, Lanzhou, China
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Background Hyperuricemia, a prevalent metabolic disorder, is witnessing a global annual increase in incidence. The gout it triggers and its link to other chronic diseases pose a severe threat to human health.The unique natural environment of high-altitude regions, characterized by low oxygen partial pressure and cold climate, may exert a distinctive influence on human metabolism, thereby impacting the onset and progression of hyperuricemia.Hospital from June to December 2024. Among them, 224 had hyperuricemia and 60 had normal uric acid levels. It collected various indicators of all subjects, including general demographic information, blood routine parameters, and biochemical markers. For univariate analysis, the t-test was used for continuous variables and the chi-square test for categorical variables to screen potential factors related to hyperuricemia. Then, a multicollinearity analysis was done on the univariate factors. After excluding variables with a VIF greater than 5, the remaining ones were put into the multivariate logistic regression model to identify the independently related factors of hyperuricemia.The incidence of hyperuricemia in the study population was 78.87%. Variables such as gender, age, red blood cell count and creatinine were found to be independently associated with hyperuricemia.This study revealed an elevated incidence of hyperuricemia in high-altitude area migrants and identified its independent related factors, offering a crucial foundation for the prevention and treatment of hyperuricemia in these regions.
Keywords: High altitude area, Hyperuricemia, Multivariate logistic regression, Creatinine, Red blood cell count, Plateau migrants
Received: 12 Jan 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Meng, Kang and Chang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: De-Hui Chang, People's Liberation Army Joint Logistics Support Force 940th Hospital, Lanzhou, China
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