Hepatokines Modulation in Obesity: which Exercise Training Model is Better in Men with Obesity?

Ali Ataeinosrat¹Hossein Abednatanzi²Shohreh Hajesfandiari²Maryam N Alnasser³Marjanmansouri Dara²Parvin Farzanegi⁴Mahnoosh salari Nahand⁵Abdullah Almaqhawi⁶Niloofar Karimi⁷Behnam Bagherzadeh-Rahmani⁸Ayoub Saeidi^9*Ismail Laher¹⁰Hassane ZOUHAL¹¹

• ¹Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Alborz, Iran
• ²Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran Iran, Tehran, Alborz, Iran
• ³Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Eastern Province, Saudi Arabia
• ⁴Islamic Azad University, Department of Physical Education & Sports Sciences, Sari Branch, Sari, Iran
• ⁵Department of Education Sciences, Farhangian University, Tehran, Iran
• ⁶Department of Family and Community Medicine, College of Medicine, King Faisal University, Al-Ahsa, Eastern Province, Saudi Arabia
• ⁷Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran, Babolsar, Mazandaran, Iran
• ⁸Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University,, Sabzevar, Iran
• ⁹Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran, Sanandaj, Iran
• ¹⁰Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
• ¹¹Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, F-35000 Rennes, France, Ren, France

Objective: Obesity is associated with an exacerbated metabolic condition that is related to impaired secretion of hepatokines. This study aimed to compare the effects of 12 weeks continuous aerobic, Tabata, and high intensity interval training (HIIT) on the levels of fetuin-A, fetuin-B, fibroblast growth factor 21 (FGF-21), plasminogen activator inhibitor-1 (PAI-1), fibrinogen-like protein 1 (FGL1), and selenoprotein P. Methods: 44 obese males were randomly divided into four groups (n=11): control group (CT), endurance training group (ET), Tabata group (Tabata), and HIIT group (HIIT). Exercise training programs lasted for 12 weeks/ three sessions per week. Each session lasted 60 minutes, containing warm-up (10 minutes), main training for each group (40 minutes), andending with cooling down (10 minutes). Measurements were made12 and 48 h before the initiation of the main interventional protocols, and then again 48 h after the final session of the training protocol. Results: Baseline data were similar in all groups (p>0.05). There was a significant group-bytime interaction for fetuin B (p=0.0004), FGF-21 (p=0.007), FGL-1 (p=0.0139), weight (p=0.0110), BMI (p=0.009), %fat (p<0.0001) and selenoprotein-1 (p=0.0052). There was a main effect of time for fetuin A and PAI-1 (p<0.0001). The reductions in fetuin B were greater in HIIT vs. CT (mean diff: -0.13) and Tabata vs. CG (mean diff: -0.14) (p<0.05), while decreases in FGF-21 were greater in ET vs. CT (mean diff: -19.1), HIIT vs. CT (mean diff: -26.22)(p<0.05), and Tabata vs. CT (mean diff: -22.8). Reductions in FGL-1 were greater in ET vs. CT (mean diff: -11.5)(p<0.05), HIIT vs. CT (mean diff: -8.1), and Tabata vs. CT (mean diff: - 11.3)(p<0.05). Conclusion: Performing 12 weeks of physical activity led to decreases in weight, BMI, %fat, fetuin-B, FGF-21, FGL-1, and selenoprotein P, and greater reduction observed in the Tabata and the HIIT groups.