ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1561062
This article is part of the Research TopicAdvancements in Nutritional Management for Patients with Renal FailureView all 4 articles
Effect of Bailing capsule complicated with low-calcium peritoneal dialysis solution on residual renal function and microinflammatory status in peritoneal dialysis patients with chronic renal failure
Provisionally accepted
- Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: This study aimed to ascertain the efficacy of Bailing capsule (BLC) combined with low-calcium peritoneal dialysis solution (PDS) in peritoneal dialysis (PD) patients with chronic renal failure (CRF). Methods: Ninety-two patients with CRF were randomly divided into a control group (n = 45) and a study group (n = 47). The control group received low-calcium peritoneal dialysis combined with a low-protein diet and compound α-ketoacid tablets, while the study group received BLC in addition to the control group's treatment. Outcome measures included clinical efficacy, residual renal function (RRF), microinflammatory status, nutritional status, oxidative stress markers, and the incidence of adverse reactions. Results: The study group demonstrated a significantly higher total effective rate compared to the control group (P < 0.05). Post-treatment, the study group exhibited a reduced rate of RRF decline, lower levels of serum tumor necrosis factor-α, C-reactive protein, and interleukin-6, improved serum prealbumin, albumin, transferrin, and hemoglobin levels, reduced serum malondialdehyde levels, and increased serum superoxide dismutase and glutathione peroxidase levels compared to the control group (P < 0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups during treatment (P > 0.05). Conclusion: The combination of BLC with low-calcium PDS is effective in PD patients with CRF, demonstrating the ability to slow the decline of RRF, improve microinflammatory status, enhance nutritional and oxidative stress parameters, and maintain a comparable safety profile without increasing the incidence of adverse reactions.
Keywords: chronic renal failure, Peritoneal Dialysis, Bailing capsule, Low-calcium peritonealdialysis solution, residual renal function, Microinflammatory state
Received: 15 Jan 2025; Accepted: 09 Sep 2025.
Copyright: © 2025 Li, Zhao, Yu, Wang, Qu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Wang, wangyu821305@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.