ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1561562
This article is part of the Research TopicNovel Strategies for the Clinical Management of Cardiovascular-Kidney-Metabolic SyndromeView all 7 articles
Different effects of regional fat masses on multiple cardiovascular-kidneymetabolic phenotypes in young adults
Provisionally accepted- 1Beijing Children’s Hospital, Capital Medical University, Beijing, China
- 2Capital Institute of Pediatrics, Beijing, Beijing Municipality, China
- 3Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To evaluate the differential effects of regional fat masses on multiple cardiovascularkidney-metabolic (CKM) phenotypes among young Chinese adults. Methods: The cross-sectional study included 1,163 participants aged 27-42 years, who underwent an assessment of whole-body and regional fat mass using dual-energy X-ray absorptiometry. We measured multiple CKM phenotypes including hypertension, hyperlipidemia, diabetes, hyperuricemia, subclinical vascular damage, and kidney damage. Results: Multivariate logistic regression analysis demonstrated that higher total fat mass index was significantly associated with increased odds of all CKM phenotypes. In models including trunk and leg fat mass, higher trunk fat mass index was independently associated with increased odds for all CKM phenotypes except for low estimated glomerular filtration rate. Conversely, higher leg fat mass index was associated with reduced odds of most CKM phenotypes, including diabetes, high triglycerides, high low-density lipoprotein cholesterol, high relative wall thickness, high brachial-ankle pulse wave velocity, and high microalbuminuria. Similarly, in models including android and gynoid fat mass, higher android fat mass was positively associated with odds of most CKM phenotypes, whereas gynoid fat mass showed negative associations. Conclusions: Regional adipose compartments confer different CKM risks in young Chinese adults, which underscores the importance of fat distribution in assessing CKM risk.
Keywords: Cardiovascular-Kidney-Metabolic diseases, Fat distribution, young adults, fat mass, CKM phenotypes
Received: 16 Jan 2025; Accepted: 02 Jun 2025.
Copyright: © 2025 Mi, Wang, Cheng, Xiong, Xiao, Junting, Shan, Hou, Zhao and YAN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Mi, Beijing Children’s Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.