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ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Cardiovascular Endocrinology

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1561562

This article is part of the Research TopicNovel Strategies for the Clinical Management of Cardiovascular-Kidney-Metabolic SyndromeView all 7 articles

Different effects of regional fat masses on multiple cardiovascular-kidneymetabolic phenotypes in young adults

Provisionally accepted
Jie  MiJie Mi1*Xia  WangXia Wang1Hong  ChengHong Cheng2Jingfan  XiongJingfan Xiong3Pei  XiaoPei Xiao1Liu  JuntingLiu Junting2Xinying  ShanXinying Shan2Dongqing  HouDongqing Hou2Xiaoyuan  ZhaoXiaoyuan Zhao2YINKUN  YANYINKUN YAN1
  • 1Beijing Children’s Hospital, Capital Medical University, Beijing, China
  • 2Capital Institute of Pediatrics, Beijing, Beijing Municipality, China
  • 3Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

Objective: To evaluate the differential effects of regional fat masses on multiple cardiovascularkidney-metabolic (CKM) phenotypes among young Chinese adults. Methods: The cross-sectional study included 1,163 participants aged 27-42 years, who underwent an assessment of whole-body and regional fat mass using dual-energy X-ray absorptiometry. We measured multiple CKM phenotypes including hypertension, hyperlipidemia, diabetes, hyperuricemia, subclinical vascular damage, and kidney damage. Results: Multivariate logistic regression analysis demonstrated that higher total fat mass index was significantly associated with increased odds of all CKM phenotypes. In models including trunk and leg fat mass, higher trunk fat mass index was independently associated with increased odds for all CKM phenotypes except for low estimated glomerular filtration rate. Conversely, higher leg fat mass index was associated with reduced odds of most CKM phenotypes, including diabetes, high triglycerides, high low-density lipoprotein cholesterol, high relative wall thickness, high brachial-ankle pulse wave velocity, and high microalbuminuria. Similarly, in models including android and gynoid fat mass, higher android fat mass was positively associated with odds of most CKM phenotypes, whereas gynoid fat mass showed negative associations. Conclusions: Regional adipose compartments confer different CKM risks in young Chinese adults, which underscores the importance of fat distribution in assessing CKM risk.

Keywords: Cardiovascular-Kidney-Metabolic diseases, Fat distribution, young adults, fat mass, CKM phenotypes

Received: 16 Jan 2025; Accepted: 02 Jun 2025.

Copyright: © 2025 Mi, Wang, Cheng, Xiong, Xiao, Junting, Shan, Hou, Zhao and YAN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jie Mi, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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