ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1566818
This article is part of the Research TopicNovel Strategies for the Clinical Management of Cardiovascular-Kidney-Metabolic SyndromeView all 13 articles
Associations between triglyceride glucose-body mass index and cardiovascular, renal, hepatic and bone biomarkers in patients with type 2 diabetes: A single-center, cross-sectional study
Provisionally accepted
- The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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Background: Type 2 diabetes (T2D) is a prevalent chronic metabolic disorder with significant global health implications, characterized by elevated blood glucose levels and a cluster of cardiometabolic risk factors. The triglyceride glucose-body mass index (TyG-BMI) has emerged as a novel index for assessing insulin resistance (IR) and cardiometabolic risk in T2D patients.Objective: This study aims to investigate the associations between TyG-BMI and the characteristics of cardiovascular, renal, hepatic and bone biomarkers in T2D patients, particularly in the context of Cardiovascular-Kidney-Metabolic (CKM) syndrome. Methods: We conducted a single-center, cross-sectional study involving 2,981 T2D patients. We assessed TyG-BMI and its correlations with the incidence of cardiovascular events, as well as bone, renal, and hepatic biomarkers. The study included 29 clinical characteristics of T2D patients to understand the progressive nature of T2D complications and the potential of TyG-BMI as a risk assessment tool. Results: Preliminary findings suggest a strong association between elevated TyG-BMI and increased trends of cardiovascular, renal, and hepatic, and bone biomarkers in T2D patients. The TyG-BMI showed significantly different trends among quartile subgroups for all identified key assessing indicators, indicating its potential as a convenient and effective tool for risk assessment.The TyG-BMI index is potentially associated with cardiovascular, renal, hepatic, and bone biomarkers in T2D patients. These findings could contribute to the development of strategies for the prevention and translational therapies of related complications in T2D patients, ultimately improving patient outcomes and reducing the burden on healthcare systems.
Keywords: type 2 diabetes, TyG-BMI, Cardiovascular biomarker, Renal biomarker, hepatic biomarker, Bone biomarker
Received: 25 Jan 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Xu, Wu, La, Zhang and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bo Cao, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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