ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1568699
This article is part of the Research TopicThyroid hormones and dietView all 14 articles
Effect of metabolism and organ function factors on the efficacy of radioactive iodine therapy for hyperthyroidism
Provisionally accepted
- Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
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Introduction: Recent studies suggest that metabolic and organ function indicators could influence radioactive iodine treatment (RAIT) efficacy in hyperthyroid patients, but their relationships with thyroid function remain unclear.Objective: This study aims to explore the impact of these markers on RAIT efficacy and thyroid function.Method: A total of 135 hyperthyroid patients undergoing RAIT were enrolled, with biomarkers collected at baseline and 1, 3, and 6 months post-treatment. These included thyrotropin receptor antibody (TRAb), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH), urinary iodine concentration (UIC), serum iodine concentration (SIC), 25-hydroxyvitamin D, alanine aminotransferase, aspartate aminotransferase, and serum creatinine (Scr). We mainly focus on the outcomes about the impact of metabolic and organ function markers on RAIT efficacy and their correlation with changes in thyroid function Results: Logistic regression identified age as a predictor of RAIT efficacy (OR = 0.957, p = 0.025), with older patients less likely to achieve clinical improvement. Scr showed borderline significance (p = 0.049). Early after treatment, SIC was positively correlated with TSH (r = 0.204, p = 0.018), whereas UIC and SIC were significantly negatively correlated with TSH at 6 months during treatment (p < 0.05). In addition, higher Scr levels were consistently and significantly associated with lower FT3 and FT4 and higher TSH at multiple time points (p < 0.05).Conclusion: Age was a relative factor influencing RAIT efficacy, while iodine nutritional status exhibited dynamic, time-dependent effects on TRAb and TSH. Elevated Scr promotes reductions in FT3 and FT4 and increase in TSH.
Keywords: Hyperthyroidism, radioactive iodine treatment, Iodine nutritional status, Vitamin D, Renal function
Received: 30 Jan 2025; Accepted: 19 May 2025.
Copyright: © 2025 Hu, Liu, Xiong, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yinlong Zhao, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
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