ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1572089
Association of Systemic Immune-Inflammation Index with Type 2 Diabetes Mellitus and Its Prognostic Significance: A Systematic Review and Meta-Analysis
Provisionally accepted
Ru Xu
Lele Jiang*- Beilun District People's Hospital of Ningbo, Ningbo, China
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Background The systemic immune-inflammation index (SII), a novel biomarker, may be associated with type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between SII and T2DM, as well as its prognostic value. Methods A comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wanfang, and Biomedical Literature Database was conducted to identify eligible studies published up to October 26, 2024. Relative risk (RR), odds ratio (OR), and hazard ratio (HR), along with their 95% confidence intervals (CIs), were extracted and synthesized. Statistical analyses were performed using Stata 15.1 software. Results 21 studies were included. SII was associated with an increased risk of major adverse cardiovascular events (MACE) and mortality. Each one-unit standard deviation (SD) increase in SII was positively correlated with MACE risk (OR/HR = 1.07; 95% CI: 1.04-1.10; P < 0.001). However, no significant association was found between SII and diabetic retinopathy. Regarding glucose metabolism abnormalities and diabetic nephropathy, high SII was significantly associated with increased risk (P < 0.05). Conclusions Elevated SII is associated with an increased risk of MACE, mortality, diabetic nephropathy and glucose metabolism abnormalities but shows no significant correlation with diabetic retinopathy.
Keywords: type 2 diabetes mellitus, systemic immune-inflammation index, Association, prognosis, Meta-analysis
Received: 06 Feb 2025; Accepted: 23 Sep 2025.
Copyright: © 2025 Xu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lele Jiang, 916573790@qq.com
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