REVIEW article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1573499
This article is part of the Research TopicCalcium Homeostasis and Cardiovascular Health: Mechanisms and Therapeutic InsightsView all 4 articles
Endoplasmic Reticulum-Mitochondria Crosstalk: New Mechanisms in the Development of Atherosclerosis
Provisionally accepted
- Hunan University of Chinese Medicine, Changsha, China
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Atherosclerosis (AS) is a global public health concern and involves a complex pathogenesis characterized by lipid abnormalities, oxidative stress, and inflammatory responses at the cellular and molecular levels. The crosstalk between the endoplasmic reticulum (ER) and mitochondria, mediated by mitochondria-associated membranes (MAMs), plays a critical role in the pathogenesis of atherosclerosis. As two key cellular organelles, the ER and mitochondria interact physically and functionally through MAMs, which serve as bridges between their close contact and interdependence. MAMs maintain lipid homeostasis, promote calcium ion transport, the oxidative stress response, apoptosis, and autophagy. Recent studies have highlighted the significance of ER-mitochondria crosstalk in the progression of AS, as indicated by mitochondrial and ER structural and functional integrity, redox homeostasis, and calcium homeostasis. This review comprehensively explores the novel mechanisms of ER-mitochondria crosstalk in AS and emphasizes the potential of MAMs as therapeutic targets, aiming to provide new perspectives and strategies for the treatment of cardiovascular diseases.
Keywords: Atherosclerosis, Endoplasmic reticulum-mitochondrial crosstalk, mitochondria-associated membranes (MAMs), endoplasmic reticulum contact complex, Endoplasmic Reticulum, Mitochondria
Received: 09 Feb 2025; Accepted: 06 May 2025.
Copyright: © 2025 Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mingxiao Li, Hunan University of Chinese Medicine, Changsha, China
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