REVIEW article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1574228
This article is part of the Research TopicRecent Advances in Gestational Diabetes: Diagnosis, Treatment and PreventionView all 6 articles
Bile Acids and Gestational Diabetes Mellitus: Exploring the Link and Implications -A Review
Provisionally accepted
- 1Department of Neonatology, Children’s Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 2Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
- 3Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan Province, China
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Gestational diabetes mellitus (GDM) represents a prevalent metabolic disorder related to pregnancy, posing significant risks to both the expecting mother and the developing fetus. Recent research indicates a potential connection between bile acids (BAs) and GDM, such as lithocholic acid (LCA), β-muricholic acid (β-MCA), and 6,7-diketolithocholic acid (6,7-diketoLCA), have been found to be significantly increased in GDM individuals, thereby with the potential to reveal their involvement in glucose metabolism and the underlying mechanisms of GDM development. Additionally, BAs have emerged as vital signaling molecules that regulate glucose and lipid metabolism by interacting with Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), highlighting their potential as novel therapeutic targets for GDM management.The aim of this manuscript is to comprehensively review the current understanding of the relationship between BAs and GDM, delving into their potential mechanistic roles, diagnostic significance, and possible therapeutic applications.
Keywords: gestational diabetes mellitus1, bile acids2, glucose homeostasis3, offspring4, therapeutic applications5
Received: 10 Feb 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Lu, Li and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoping Lei, Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
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