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ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Developmental Endocrinology

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1576240

This article is part of the Research TopicPlacental Dysfunction in Pregnancy: Endocrine and Metabolic Mechanisms in Preeclampsia, FGR, Diabetes, and HypertensionView all 4 articles

Dual specificity phosphatase 1 as a non-invasive circulating biomarker candidate in preeclampsia

Provisionally accepted
Jonatane AndrieuJonatane Andrieu1Agathe DonetAgathe Donet2Jean-françois CocallemenJean-françois Cocallemen2Guillaume CharbonnierGuillaume Charbonnier3Noémie ResseguierNoémie Resseguier2Julien PAGANINIJulien PAGANINI3Jean-louis MegeJean-louis Mege2Soraya MEZOUARSoraya MEZOUAR1*Florence BretelleFlorence Bretelle2
  • 1Aix-Marseille university, Marseille, France
  • 2Aix-Marseille Université, Marseille, Provence-Alpes-Côte d'Azur, France
  • 3Xegen SAS, Gemenos, France

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This single-center prospective longitudinal characteristics' study was conducted in accordance with the Declaration of Helsinki and the French law on research involving humans. The protocol of the study was approved by an independent national review board ethics committee "CPP Sud Mediterranean 1" n° 2010-A00633-36. All pregnant women provided written informed consent and were recruited at the gynecology-obstetrics department of the "Hôpital de la Conception" and "Hôpital Nord" (Marseille, France) from February 2019 and July 2020. Author contribution J.A and A.D; and S.M, J.L.M and F.B contributed equally to this work. J.A and A.D were involved in experimental design and execution, data analysis and figure generation. A.D and J.F.C collected samples used in these experiments and participate to experiments. G.C and J.P realized RNAseq data analysis and figure generation. A.D and F.B initiated the clinical study and participated in the analysis of the clinical characteristics of the cohort. N.R carried out the statistical analyses. S.M, J.L.M and F.B contributed expertise in the guidance for experimental design, supervised the study and manuscript preparation and mentorship.

Keywords: Preeclampsia, Placenta, Hypertension, DUSP1, RNAseq

Received: 13 Feb 2025; Accepted: 23 Jul 2025.

Copyright: © 2025 Andrieu, Donet, Cocallemen, Charbonnier, Resseguier, PAGANINI, Mege, MEZOUAR and Bretelle. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Soraya MEZOUAR, Aix-Marseille university, Marseille, France

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material