Visceral Adiposity Loss is Associated with Improvement in Cardiometabolic Markers: Findings from a Dietary Intervention Study

Shazana Rifham Abdullah^1*Ahmad Kamil Nur Zati Iwani¹Liyana Ahmad Zamri¹Ruziana Mona Wan Mohd Zin¹Norhashimah Abu Seman¹Nur Azlin Zainal Abidin¹Siti Sarah Hamzah¹Nur Hayati Azizul¹Azahadi Omar²Zamtira Seman²Abqariyah Yahya³Mohd Fairulnizal Md Noh¹

• ¹Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia
• ²Sector for Biostatistics and Data Repository, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia
• ³Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia

Background: Visceral adiposity is closely linked with cardiometabolic disorders, but evidence on the extent of visceral fat loss required for significant improvement in cardiometabolic markers remains limited. This study aims to investigate the association between visceral fat area (VFA) reductions and improvements in cardiometabolic markers following a 3-month dietary intervention.Methods: A total of 175 adults with overweight and obesity were involved in this non-randomized controlled trial. Data on sociodemographic, anthropometric, body composition and biochemistry were collected at baseline and after 3 months of intervention. The multiple logistic regression analysis was conducted to determine the association between VFA loss (no loss, < 5% loss, and ≥ 5% loss) and improvement in cardiometabolic markers. For each cardiometabolic marker, an improvement surpassing the minimum threshold of the third tertile was classified as a good improvement.Results: Compared to those with no VFA loss, participants with VFA loss of ≥ 5% were significantly associated with a higher improvement in waist circumference (OR 2.97,), highdensity lipoprotein cholesterol (HDL-C) (OR 4.19,, triglycerides (OR 3.01, 95% CI 1.14-7.92), and glycated hemoglobin (HbA1C) (OR 2.95, 95% CI 1.12-7.79). Other than that, those with < 5% VFA loss were 3.6 times more likely to have a higher improvement in HDL-C compared to those with no VFA loss (OR 4.08,. Conclusion: This study found that the magnitude of VFA loss is an independent determinant of improvements in cardiometabolic markers and should be set as a clear target when designing obesity prevention programs.