REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1577758
This article is part of the Research TopicGenetic and Molecular Determinants in Bone Health and Diseases - Volume IIView all 9 articles
Updated Review on Osteosarcopenia: Epidemiology，Molecular Mechanisms and Management
Provisionally accepted
- Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
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Osteosarcopenia(OS ) , a recently recognized syndrome characterized by the simultaneous occurrence of osteopenia/osteoporosis and sarcopenia, has emerged as an important concept in clinical practice. This integrated framework provides a comprehensive view of the musculoskeletal system, addressing a previously underappreciated aspect of muscle health. OS notably increases the risk of falls, fractures, hospitalization, and mortality in elderly patients with chronic diseases.Despite its growing clinical relevance, OS remains underdiagnosed, and its classification as a distinct syndrome is not universally accepted. The persistently high global prevalence of chronic diseases, along with their substantial medical, economic, and social burdens, underscores the urgent need for updated prevention and management strategies. This review advocates for greater awareness and improved management of OS in patients with chronic diseases. It examines the relationship between OS and chronic conditions, emphasizing its epidemiology, adverse outcomes, diagnostic approaches, pathophysiology, and potential management strategies.
Keywords: osteosarcopenia, Osteoporosis, Sarcopenia, chronic diseases, chronic inflammatory disease. mesenchymal stem cell therapy
Received: 16 Feb 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Yi, Zhao, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei-zhou Wang, Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
Xi Li, Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
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