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SYSTEMATIC REVIEW article

Front. Endocrinol.

Sec. Renal Endocrinology

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1578045

Research on Podocyte Injury Mechanisms in Diabetic Nephropathy: A Bibliometric and Knowledge-Map Analysis from 2000 to 2024

Provisionally accepted
Yanm  LinYanm LinJianqing  TianJianqing Tian*
  • Department of Endocrinology, Xiang'an Hospital, Xiamen University, Xiamen, China

The final, formatted version of the article will be published soon.

Objectives: A bibliometric and knowledge-map analysis is used to explore hotspots evolution and development trends in the Podocyte Injury Mechanisms in Diabetic Nephropathy. By looking for research hotspots and new topics, we can provide new clues and ideas for researchers in this field. Methods: The articles and reviews regarding Podocyte were retrieved and obtained from the Web of Science Core Collection (WOSCC) on September 1st, 2024. CiteSpace [version 6.2.4R (64-bit)] and VOSviewer (version 1.6.18) were used to conduct the bibliometric and knowledge-map analysis. Results: 12086 authors from 2394 institutions in 69 countries/regions published 3239 papers in academic journals. PEOPLES R CHINA and THE USA were absolutely in the leading position in this research field. The institution that contributed the most publications was Shandong University. Kidney International (130 articles) is the journal with the most published records and the highest number of co-citations. The author with the highest number of co-citations is Mundel p. However, there was little cooperation between countries. After 2012, cooperation among various institutions was also limited. Autophagy, mitochondria, and epigenetics are hot topics and trends in this field. The most influential research hotspots were the research of podocyte autophagy and metabolism, the related research of SIRT1, VEGF. The latest hotspots and topics included the study of nlrp3 inflammasome and signaling pathway in podocyte injury.The research of Podocyte in Diabetic Nephropathy was a rapidly developing hot field.The damage mechanism of podocytes is a very important factor in the occurrence and progression of diabetic nephropathy. Early intervention for podocyte damage is a very potential preventive measure for diabetic nephropathy, which has clinical application prospects and is currently developing rapidly.

Keywords: VOSviewer, Citespace, bibliometrics analysis, Bibliometrix, Podocyte injury, dn

Received: 18 Feb 2025; Accepted: 01 Jul 2025.

Copyright: © 2025 Lin and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jianqing Tian, Department of Endocrinology, Xiang'an Hospital, Xiamen University, Xiamen, China

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