REVIEW article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1579457
This article is part of the Research TopicInterplay between Glucose and Lipid Homeostasis in Metabolic HealthView all 4 articles
Metabolic Disturbances in Acute Pancreatitis: Mechanisms and Therapeutic Implications
Provisionally accepted
- Jinhua Municipal Centeral Hospital, Jinhua, China
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Acute pancreatitis (AP) is a common inflammatory condition of the pancreas that is often associated with metabolic disturbances resulting from pancreatic injury. This review examines the intricate relationship between metabolic abnormalities, such as changes in lipid and glucose metabolism, and the pathophysiology of AP. While these metabolic disturbances do not directly cause AP, they can significantly worsen the progression and severity of the disease. For instance, hypertriglyceridemia can increase pancreatic necrosis through mechanisms like lipotoxicity and oxidative stress. Similarly, disorders in glucose metabolism can further damage pancreatic cells by heightening inflammatory responses and oxidative stress. Additionally, we investigate novel metabolic interventions, including lipase inhibitors, insulin therapy, and antioxidants, designed to address these metabolic disturbances and reduce the severity of the disease. Understanding how metabolic disturbances contribute to the progression of AP is crucial for developing effective therapeutic strategies and improving patient outcomes.
Keywords: metabolic disturbances1, acute pancreatitis2, lipid metabolism3, glucose metabolism4, Oxidative stress5
Received: 19 Feb 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Chao, Ding, Wang and Teng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xusheng Teng, Jinhua Municipal Centeral Hospital, Jinhua, China
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