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CASE REPORT article

Front. Endocrinol.

Sec. Clinical Diabetes

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1580568

A case series of using ultrasound-guided continuous parasacral ischial plane blocks to promote ulcer healing and pain relief in people with diabetic foot ulcers

Provisionally accepted
Peng  YePeng YeXuan  PanXuan PanJing  ZhuangJing ZhuangHanliang  FanHanliang FanXiaochun  ZhengXiaochun ZhengTing  ZhengTing Zheng*
  • Fujian Medical University, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

Background: Diabetic foot ulcers (DFU) are a prevalent complication of diabetes, leading to significant morbidity, mortality, and amputation rates. Chronic non-healing DFU often result from peripheral neuropathy, microvascular issues, and infection, with poor blood and oxygen supply being critical factors in delayed healing. The development of new treatments to promote blood supply and accelerate ulcer healing is a significant area of research for DFU management.In this case series, nine patients with chronic diabetic ulcers received ultrasound-guided continuous parasacral ischial plane block (CPIPB) for 2 weeks, combined with standard care (SOC) for 12 weeks. Our objective was to assess the reduction in wound size and the rate of complete healing 12 weeks after the start of treatment.Results: Among the nine patients, six achieved complete healing of their diabetic foot ulcers, while the remaining three showed significant improvement with more than a 50% reduction in the initial ulcer area. This approach not only provided analgesia but also increased foot skin temperature and blood supply in the lower limb arteries, potentially promoting angiogenesis and revascularization. Local anesthetic leakage at the catheter insertion site occurred in two cases during CPIPB.CPIPB can promotes diabetic foot ulcer healing while providing effective analgesia in the lower limbs. This approach may offer a valuable complement to conventional treatments, particularly for patients with severe pain.

Keywords: Diabetic foot ulcers, pain relief, Parasacral ischial plane block, Ultrasound-guided, Angiogenesis

Received: 21 Feb 2025; Accepted: 05 Aug 2025.

Copyright: © 2025 Ye, Pan, Zhuang, Fan, Zheng and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ting Zheng, Fujian Medical University, Fuzhou, 350108, Fujian Province, China

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