ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1585144
Development and Validation of a Nomogram Model for Sleep Disorders in Patients with Recurrent Implantation Failure Based on Physiological and Lifestyle Factors
Provisionally accepted
- 1Shanghai First Maternity and Infant Hospital, Shanghai, China
- 2Sanda University, Shanghai, Shanghai Municipality, China
- 3Tongji University, Shanghai, Shanghai Municipality, China
- 4Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
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Objective: To establish and validate a nomogram model for the quality of sleep in patients with recurrent implantation failure (RIF) and to evaluate its performance. Methods: From January 2023 to June 2023, 484 RIF patients who underwent ART fertilization treatment at the Reproductive Medicine Center of Tongji University-affiliated Obstetrics and Gynecology Hospital were selected as the modeling set and internal validation. Additionally, from July to September 2023, 223 RIF patients who underwent ART fertilization treatment at the Reproductive Medicine Center of Tongji University-affiliated Obstetrics and Gynecology Hospital were chosen as the external validation set. Their clinical data was collected. Lasso regression was used to screen potential predictive variables and multifactor logistic regression analysis was conducted to determine the final predictors. A nomogram model was established, and the model was evaluated using methods such as plotting receiver operating characteristic (ROC) curves, calibration curves, Hosmer-Lemeshow goodness of fit test, and decision curve analysis. Results: Through Lasso regression and multifactor logistic regression, 7 predictors were identified, including FSH, E2, depression mood (moderate, severe), daily exercise time, sun exposure, caffeine intake, and shift work (>16h/w) for constructing the nomogram model. The AUC for the modeling set was 0.971 (95%CI:0.952～0.989), for the internal validation set was 0.960 (95%CI:0.937～0.979), and for the external validation set was 0.850 (95%CI:0.739～0.960), indicating good predictive performance of the model. Conclusion: This study established and validated a nomogram model composed of 7 clinical indicators for sleep disorders in RIF patients. The predictors include both physiological indicators and daily lifestyle habits, demonstrating significant predictive value and clinical application efficiency. It can be used for early identification of potential sleep disorders in RIF patients, providing certain reference significance for clinical work.
Keywords: recurrent implantation failure of embryos, sleep quality, Prediction model, LASSO regression, nomogram
Received: 06 Mar 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Zhang, Qin, Hu, Bai, Pan, Xu, Huang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ke Wang, Shanghai First Maternity and Infant Hospital, Shanghai, China
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